Management of blood born viruses

Question 1

What is the baltimore classification for HCV, HIV and HBV

Question 2

What is a viral cycle?

Answer 2

1) Attachment
2) Penetration
3) Uncoating - release nuclear material
4) Replication and integration
5) Assembly
6) Release and maturation

Question 3

What aspect of the virus interacts with the receptors of the host cell?

Answer 3

polypeptide binding sites on the envelope or capsid

Question 4

What enzyme translate the mRNA in the host cell?

Answer 4

RNA polymerase

Question 5

What enzyme copies retroviruses? (HIV)

Answer 5

Reverse transcriptase enzyme

Question 6

What sort of DNA can stay in liver cells and can be reactivated?

Answer 6

cccDNA (covalent….DNA)

Question 7

What enzyme is needed for the integration of HIV? what hep does not integrate?

Answer 7

integrase enzyme (found within HIV).

Hep C does not integrate and has no reverse transcriptase activity

Question 8

What does the pro-protein/polyprotein do in HIV and Hep C?

Answer 8

need to chopped up to (cleavage) an and made functional by encoded protease

Question 9

What are the targets are the envelops of HIV

Answer 9

GP120, CD4 OR

CCRS, GP120 OR
GP41

Maraviroc binds to CCRS and Enfuvirtide binds to GP41

Question 10

RT inhibitors examples?

Answer 10

NRTIs
NtRTIs
NNRTIs or non-nukes (bind to RT/polymerase enzyme)

Question 11

First line for chronic Hep B?

Answer 11

1) interferons

2) Nucleoside inhibitor