Diuretics and Glaucoma

Question 1

What is the most commonly prescribed medication for the reduction of intraocular pressure in acute open angle glaucoma?

Answer 1

• Acetazolamide (carbonic anhydrase inhibitor): used to treat acute angle closure glaucome

Question 2

What is the site of action of Frusemide and what channel or carrier does it block?

Answer 2

Ascending loop of henle - Na/K Cl carrier

Question 3

What is the site of action of Thiazides and what channel or carrier does it block?

Answer 3

Distal tubule and connecting segment - Na/Cl carrier

Question 4

What is the site of action of sprionolactone and what channel or carrier does it block?

Answer 4

Cortical collecting tubule - Na/K ATPase pump