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Psychiatry > Management 2 > Flashcards

Management 2 Flashcards

1
Q

What are the indications of TCAs?

A

Depression

Amitriptyline: Neuropathic pain

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2
Q

What are the SEs of TCAs?

A

Antimuscarinic: Dry mouth, blurred vision, constipation
ECG changes & arrhythmia
Sexual dysfunction
EP signs: Tremor, dyskinesia

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3
Q

What are the interactions of TCAs?

A

Monoamine Oxidase inhibitors- precipitate serotonin syndrome

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4
Q

What are the indications of acetylcholinesterase inhibitors?

A

Dementia & Alzheimer’s disease (Donepezil)

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5
Q

What is the mechanism of action of acetylcholinesterase inhibitors?

A

Inhibits acetylcholinesterase enzyme from breaking down acetylcholine
Increasing level & duration of action of neurotransmitter acetylcholine

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6
Q

What are the SEs of acetylcholinesterase inhibitors?

A 
N&V
Insomnia
Headache
Fatigue
Abnormal dreams
Muscle cramps
Aggression & agitation
Incontinence
Rash/pruritis
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7
Q

What are the interactions of acetylcholinesterase inhibitors?

A

Antihistamines
Antipsychotics
Tricyclics

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8
Q

What are the indications of anxiolytics?

A

E.g Benzos
Seizure & status epilepticus
Severe, disabling, distressing anxiety (short term)
Severe, disabling, distressing insomnia

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9
Q

What is the mechanism of action of anxiolytics?

A

Target GABA receptors enhancing binding.

Main inhibitory neurotransmitter

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10
Q

What are the contraindications of anxiolytics?

A

Neuromuscular disease: Myasthenia Gravis

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11
Q

What are the SEs of anxiolytics?

A

Drowsiness/sedation
Dependence
Withdrawal
Overdose: Loss of airway reflexes= airway obstruction & death

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12
Q

What are the interactions of anxiolytics?

A

Alcohol
Opioids
Additive effect

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13
Q

Name some 1st and 2nd generation antipsychotics..

A

1st: Haloperidol, Levomepromazine, Chlorpromazine
2nd: Risperidone, Olanzapine, Clozapine, Quetiapine

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14
Q

What is the mechanism of action of antipsychotics?

A

Reduce the amount of dopamine in the brain
Block D2 receptors in the CNS
Restore balance of dopamine with other neurotransmitters

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15
Q

What are the indications for antipsychotics?

A 
Psychosis
Schizophrenia
Schizoaffective disorder
Personality disorder
Bipolar
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16
Q

What are the SE specific to Olanzapine?

A

Weight gain
Diabetes
Sedation

Psychiatry (19 decks)

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