Core Conditions 3 Flashcards
What is a conversion disorder?
Voluntary motor or sensory function deficits that suggest neurological or medical conditions but are rather associated with clinical findings that are not compatible with such conditions
What are the signs & symptoms of a conversion disorder?
Unconventional behaviour during Hx Emotional processing problems Recent/remote life stressors Multiple illness behaviours Give-way weakness Unusual neuro deficits Inconsistent exam findings False sensory findings Distractible symptoms Bizarre movements Generalised seizure-like motor movements without loss of awareness Gait disorders
How is a conversion disorder managed?
CBT
Hypnosis
Biofeedback training
Benzos: Lorazepam
What are the 5 stages of grief?
- Denial
- Anger
- Bargaining
- Depression (>50%)
- Acceptance
Define: Learning Disability Learning Difficulty Mental retardation Cognitive impairment
LDi: Occuring before 18 with loss of adaptive social functioning and an IQ under 70 (Same as mental retardation- ICD-10)
LDif: E.g dyslexia/dysphraxia, specific learning disability, used by educational services
CI: Below average IQ
What is serotonin syndrome?
An excess of synaptic serotonin in the central nervous system that clinically manifests as the triad of neuromuscular excitation, autonomic effects, and altered mental status.
What are the causes of serotonin syndrome?
Drug overdose (SSRI)
Drug interactions (MAOIs)
Therapeutic meds
Mixing medications: e.g St John’s Wort & SSRI
What is the pathophysiology of serotonin syndrome?
- Exposure to any med that increases the intrasynaptic serotonin conc in the CNS
- Has effects on 5HT receptor subtypes
- Mechanisms:
- Increased serotonin production
- Serotonin release
- Serotonin reuptake inhibition
- Decreased serotonin metabolism (MAOI)
- Severe almost always due to synergistic effects of 2 serotonergic drugs via different mechanisms (usually SSRI & MAOI)
What are the signs & symptoms of serotonin syndrome?
Severe HTN Tachycardia High pyrexia (sweating) Anxiety & agitation Confusion Tremor, shivering, muscle jerks Headache Neuromuscular: Increased tone, myoclonus, hyper-reflexia Hypertonia/rigidity
How is serotonin syndrome investigated?
Hx & Ex Other investigations (FBC, CPK, Urine tox to rule other causes out)
How is serotonin syndrome treated?
MILD: Cessation of causative drug
MOD: Cessation of drug, Diazepam5-10mg/Cyproheptadine 12mg
SEVERE: Cessation of drug, Activated charcoal 25-100mg, Chlorpromazine 12.5-50mg
Rhabdomyolysis: Muscle paralysis & cooling
What are the complications of serotonin syndrome?
Rhabdomyolysis
Multi-organ failure
How is the severity of serotonin syndrome categorised?
Mild: Hyper-reflexia (almost always with SSRI use), tremor, inducible clonus, non-specific (headache, sweating), diaphoresis, myoclonic jerks
Moderate: Cause signif distress, patient requires treatment, anxiety & agitation, tachycardia, meet HSTC criteria
Severe: MEDICAL EMERGENCY, multiorgan failure if not treated, hyperthermia, hypertonia, meet HSTC criteria
What are examples of functional somatic syndromes?
GI: IBS Gynae: Pre-menstrual syndrome, chronic pelvic pain Rheumatology: Fibromyalgia Cardio: Atypical/ Non-cardiac chest pain Resp: Hyperventilation Infectious: Chronic fatigue syndrome Neuro: Tension headache ENT: Globus syndrome Allergy: Multiple chemical sensitivity
What are the criteria for chronic fatigue syndrome?
>4 more: Headache Unrefreshing sleep Joint/muscle pain Tender lymph nodes Subjective memory impairment Postexertional malaise >24hours