Mammary gland and mastitis Flashcards
What is the average and peak lactation for a Holstein milk cow?
Average 65-85 lbs/day
Peak lactation 100-140 lbs/day
What is the economic impact on mastitis in a dairy herd?
Economic impact of mastitis o 40% morbidity on dairy farms o most costly cattle disease in US o est to cost 2 billion/yr o est $200-300/cow
The function of the median suspensory ligament
o Most important structure
o Supports and separates the two lateral halves
“Sag Bags” occur when the median ligament gives out.
T/F: The front and back quarters of an udder are separated by a thin membrane
True
T/F: There is crossover in the duct system of the udder
False. Each quarter is a separet unit. however, abx fused into one quarter will quickly find their way to other quarters via the bloodstream
Which teats are longer?
The front
What are the 3 main barriers to protect against intra-mammary infections?
o Teat skin condition
o Teat end condition
o Keratin lining of streak canal
The function and appearance of the secretory parenchyma
Secretory parenchyma – grape-like clusters of myoepithelial tissue, express milk under influence of oxytocin
The function of the ducts
Ducts – lead from secretory tissue to cistern - lobes composed of alveoli release milk into ducts
The function of the cisterns
Cisterns – gland cistern and teat cistern
Milk available in the cisterns between milkings is 100-400 ml/quarter
Function of the streak canal. Name a management practice used to keep it clean.
Streak canal - lined with epithelium and keratin that lines teat and has a good protective feature that helps with sealing the teat end. Eat after they come out of the milking parlor so that the streak canal can close before they go lay down in the manure.
What happens to the sphincter muscle at the end of the teat when the milk is sucked out?
Sphincter muscle around the end of the teat - as milk is sucked out, sphincter expands until it can’t stretch anymore, leads to speeding up speed of milk and this can lead to removal of keratin
Where are the notable lymphnodes of the udder and why would they get enlarged?
2 big Lymph nodes in the back of the udder, lymphosarcoma is the reason why they get enlarged.
What does allometric growth mean in reference to udder development?
Mammary tissue develops at an accelerated rate between 3 months and puberty = allometric growth
What happens if the calf is fed too much during udder development?
Mammary tissue grows a lot faster than rest of calf - if fed at growth rates at over 2 lbs per day - the fat pad in the udder is grown at the expense of the rest of the udder.
Overfeeding in this period can lead to excess deposition of fat in the udder and reduce milk secretion capacity later in life
What is the consequence of underfeeding a calf during udder development?
impairs udder development
what is the predominant hormone governing synthesis of milk in cattle?
Growth hormone (it is prolactin in non-ruminants)
What is the physiology behind keeping cows from “drying up”?
Frequent removal of milk minimized the effects of feedback inhibition (mechanism used to “dry off” cows at end of lactation) - feedback inhibitor of lactation protein - if removed by milking cow, feedback inhibition is removed - so more often cow is milked, the more milk we get
How does oxytocin induce milk ejection?
Oxytocin is:
o Triggered by stimulation of the teats and other situational triggers (ex. entering the milk parlor)
o Travels from pituitary to mammary gland via bloodstream
Delay of 60-90 seconds = “milk let down time”
o Oxytocin causes myoepithelial cells to contract and eject milk into ducts - expresses the milk that Is already in the alveolus - has no effect on making more milk
How many seconds does it take for the milk to be “let down”?
60-90 seconds
What hormone antagonizes oxytocin release and how doe we prevent it?
Adrenalin is a powerful antidote to oxytocin release – hence milking parlor must be calm and quiet
What drives the dry matter intake of a dairy cow?
Dry matter intake is driven by milk product
What is the “main” barrier to infection of the teat?
The teat canal
What immune cells constitute the major response to bacterial pathogens in the udder?
PMNs (somatic cells) constitute major cellular response to bacterial infection – no immune memory