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PPP-3 > Malignant Heme > Flashcards

Malignant Heme Flashcards

1
Q

Bleomycin (cytotoxic chemo)

A

Mechanism: inhibit DNA synthesis
Indication: HL
AEs: lung toxicity, pneumonitis, cytopenias

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2
Q

Cyclophosphamide (cytotoxic chemo)

A

Mechanism: alkylating agent that crosslinks DNA strands
Indication: ALL, NHL, myeloma, stem cell transplant, immunosupressant
AEs: neuropathy, AML, hemorrhagic cystitis, cytopenias, hair loss, GI

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3
Q

Doxorubicin (cytotoxic chemo)

A

Mechanism: anthracycline that inhibits topo II
Indications; AML, ALL, NHL, HL
AEs: cardiac failure, neuropathy, MDS, AML, cytopenias, hair loss, GI

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4
Q

Etoposide (cytotoxic chemo)

A

Mechanism: inhibit topo II
Indications: small cell lung cancer, testicular cancer, HL, NHL
AEs: neuropathy, MDS, AML, cytopenias, hair loss, GI

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5
Q

Hydroxyurea (cytotoxic chemo)

A

Mechanism: antimetabolite and stops ribonucleotides to convert to deoxyribo
Indications: myeloproliferatie neoplasms and sickle cell
AEs: macrocytosis, mucocutaneous lesions/ulcers

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6
Q

L-asparaginase (cytotoxic chemo)

A

Mechanism: cause leukemia cell apoptosis
Indication: ALL
AEs: thrombosis, liver failure, hypersensitivity

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7
Q

Methotrexate (cytotoxic chemo)

A

Mechanism: folate analogue that inhibits DNA synthesis
Indication: ALL, NHL, CNS lymphoma, autoimmune diseases
AEs: lots

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8
Q

Vinka alkaloids (cytotoxic chemo)

A

Mechanism: inhibit microtubule formation
Indication: HL, NHL, ALL, sarcoma, testicular cancer
AEs: neuropathy and constipation

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9
Q

ATRA (targeted chemo)

A

Mechanism: induce differentiation of promyelocytes
Indication: APL
AEs: fever, respiratory failure, fluid overload, multi-organ failure

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10
Q

Venetoclax (targeted chemo)

A

Mechanism: BCL-2 inhibitor
Indication: CLL, AML
AEs: cytopenias

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11
Q

Ibrutinib (targeted chemo)

A

Mechanism: BTK inhibitor
Indication: CLL, NHL
AEs: cytopenias, afib, bleeding

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12
Q

Imatinib (targeted chemo)

A

Mechanism: 1st gen BCR-Abl TK inhibitor
Indication: CML, ALL
AEs: fluid retention and GI upset

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13
Q

Dasatinib and nilotinib (targeted chemo)

A

Mechanism: 2nd gen BCR-Abl TK inhibitor
Indication: CML, ALL
AEs: D causes pleural effusions and N causes Qt prolongation

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14
Q

Ruxolitinib (targeted chemo)

A

Mechanism: JAK inhibitor
Indication: Myelofibrosis, PV
AEs: cytopenias

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15
Q

Lenalidomide

A

Mechanism: enhance T cell and NK cell mediated cytotox and direct tox for myeloma cells
Indication: myeloma and MDS
AEs: cytopenias and thrombosis

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16
Q

Rituximab

A

Mechanism: mab against CD-20 on B cells
Indication: B cell lymphomas and AI disorders
AEs: can reactivate viruses like hep B

17
Q

Brentuximab

A

Mechanism: antibody drug conjugate direct at CD30 allowing release of microtubule disrupting agents
Indication: CD30+ lymphoma, HL, many T cell lymphomas

PPP-3 (21 decks)

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