Hematopoietic stem cell transplant

Question 1

Oprelvekin

Answer 1

MOA: endogenous IL-11 that increases platelets
I: thrombocytopenia
CI: myeloid malignancies, thrombocytosis

Question 2

Anagrelide

Answer 2

MOA: decreases megakaryocyte development that decreases platelets
I: thrombocytosis
CI: thromocytopenia

Question 3

EPO

Answer 3

MOA: increases RBCs
I: anemia (not Fe deficiency)
CI: high Hct or Hb, myeloid malignancies, uncontrolled HTN

Question 4

Sargramostim

Answer 4

MOA: exogenous GM-CSF that increases everything
I: neutropenia, increase stem cell transplant success
CI: myeloid malignancies, leukocytosis, radiation/chemo, thrombocytosis

Question 5

Plerixafor

Answer 5

MOA: CXCR4 antagonist
I: HSC harvesting and mobilization