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Hematology > Malignancies of lymphoid cells > Flashcards

Malignancies of lymphoid cells Flashcards

1
Q
A

ALL

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2
Q

Most common childhood cancer

A

B cell ALL

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3
Q

Poor prognostic factors in ALL

A

t(9;22)

High leukocyte count

Symptomatic CNS disease

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4
Q

Most common lymphoid leukemia

A

Chronic lymphoid leukemia

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5
Q

Non hodgkin Lymphomas with female preponderance

A

Follicular lymphoma

Marginal Zone B cell lymphoma of MALT type

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6
Q

NHLs common in children

A

Precursor T cell lymphoblastic lymphoma (40%)

Burkitt lymphoma (30%)

Diffuse large B cell lymphoma (25%)

Peripheral T cell non hodgkin lymphoma (5%)

Anaplastic large T/Null cell lymphoma

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7
Q

International prognostic index for NHL

A
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8
Q

B symptoms are common in which NHLs

A

Anaplastic large T/null cell lymphoma

Peripheral T cell non hodgkin lymphoma

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9
Q

NHLs which doesnot involve bone marrow commonly

A

Anaplastic large T/Null cell lymphoma

MALT

DLBCL

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10
Q

NHLs with good prognosis

A

NHL

% surviving 5 years

Anaplastic large T/Null cell lymphoma

77%

MALT

74%

Follicular

72%

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11
Q
A

CLL

Smudge or basketcells

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12
Q

Cytogenetic abnormalities in CLL

A

trisomy 12

abnormalities in chromosome 13

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13
Q

Diagnosis of typical B cell CLL is made when the number of circulating lymphocytes is more than

A

4000/µL

These are monoclonal B cells expressing CD5

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14
Q

CD5 positive NHLs

A

Mantle cell lymphoma

B cell CLL

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15
Q

Tissue manifestation of waldenstrom macroglobulinemia

A

Lymphoplasmacytic lymphoma

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16
Q

Lymphomas similar to SLL

A

Mantle cell lymphoma

Nodal marginal zone B cell lymphoma

lymphoplasmacytic lymphoma

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17
Q

The diagnosis of typical B cell CLL should be considered in any patient with

A

Autoimmune hemolytic anemia

Autoimmune thrombocytopenia

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18
Q

Poor prognostic markers in CLL

A

CD38

ZAP 70

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19
Q

Lumbar puncture is needed in which NHLs

A

Lymphoblastic

burkitt

DLBCL

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20
Q

Treatment for CLL/SLL

A

Oral Chlorambucil

IV Fludarabine(more active)

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21
Q

Drug equally efficacious as fludarabine in CLL

A

Bendamustine

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22
Q

MALT lymphomas

A

Site

Disease

Stomach

H.Pylori

Thyroid

Hashimoto thyroiditis

Salivary gland

Sjogren

Ocular

Chlamydia psitacci conjunctivitis

Skin

Borrelia

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23
Q

Translocation in MALT lymphoma

A

t(11;18)

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24
Q

Determining factor in progression of MALT lymphoma to DLBCL

A

t(11;18) negativity

BCL 6 mutations

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25
Q

translocation in mantle cell lymphoma

A

t(11;14)

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26
Q

Overexpression of _____________ leads to mantle cell lymphoma

A

BCL1/CYCLIN D1

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27
Q

Difference btw mantle cell lymphoma and SLL

A

Mantle cell lymphoma has a slightly indented nucleus

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28
Q

GI involvement of mantle cell lymphoma

A

Lymphomatosis polyposis of large intestine

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29
Q

Mantle cell lymphoma patients with GI involvement usually have involvement of

A

waldeyer ring

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30
Q

Treatment of mantle cell lymphoma

A

Hyper CVAD

Cyclophosphamide

Vincristine

doxorubicin

dexamethasone

cytarabine

methotrexate

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31
Q

Translocation in follicular lymphoma

A

t(14;18)

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32
Q

Abnormal expression of ___________ protein is seen in follicular lymphoma

A

BCL2

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33
Q
A

Small cleaved cells

large cells

arranged in follicular pattern

follicular lymphoma

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34
Q

Follicular lymphoma must be differentiated from

A

Reactive follicular hyperplasia

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35
Q

Most common presentation of follicular lymphoma

A

new

painless

lymphadenopathy

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36
Q

Transformation of follicular lymphoma to DLBCL is heralded by

A

Rapidly enlarging nodes

B symptoms

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37
Q

Most common type of NHL

A

DLBCL

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38
Q

Transformation of CLL to DLBCL

A

Richter syndrome

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39
Q

Primary mediastinal DLBCL

A

Common in females

Younger median age(37 years)

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40
Q

Most common extranodal sites of DLBCL

A

Gi tract

Bone marrow

41
Q

Treatment of DLBCL

A

R-CHOP

42
Q

Which is better in relapsed DLBCL?

Autologus BMT or salvage chemotherapy

A

Autologus BMT

43
Q
A

Medium sized lymphocytes

Frequent mitotic figures

Burkitt Lymphoma

44
Q

Translocations in burkitt lymphoma

A

t(8;14)

t(2;8) lambda

t(8;22) kappa

45
Q

Clinical forms of burkitt

A

Endemic

Sporadic

Immunodeficiency associated

46
Q

Difference between burkitt lymphoma and DLBCL

A

Extremely high proliferative fraction in burkitt lymphoma

47
Q

Burkitt lymphoma commonly metastasises to

A

CNS

48
Q

Treatment of burkitt lymphoma must begin within

A

48h of diagnosis

49
Q

Treatment of burkitt lymphoma

A

Combination regimen with high dose chemotherapy

Prophylactic therapy to CNS

50
Q

Hairy cell leukemia typically presents with

A

Pancytopenia

51
Q

Staining in Hairy cell leukemia

A

Tartrate resistant acid phosphatase

52
Q

Who are affected by hairy cell leukemia?

A

Older males

53
Q

Diseases associated with hairy cell leukemia

A

MAC infection

Vasculitic syndromes

54
Q

Rx of hairy cell leukemia

A

Interferon alpha

pentostatin

CLADRIBINE

55
Q

Lymphoma associated with Hepatits C

A

Lymphoplasmacytic lymphoma

56
Q

Other name for nodal marginal zone lymphoma

A

Monocytoid B cell lymphoma

57
Q

Presentation of Precursor T cell lymphoblastic lymhoma

A

Young Men

Mediastinal mass

Pleural effusion

CNS mets

58
Q

Stages of mycosis fungoids

A

Patch►Plaque►Tumor

59
Q

Sezary syndrome

A

Mycoses fungoids with erythroderma and circulating tumor cells

60
Q

Treatment of mycosis fungoides

A

Early stage:

Total skin electron beam radiation

Later stages:

Topical glucocorticoids

Topical Nitrogen mustard

PUVA

Phototherapy

Extracorporeal photopheresis

Retinoids

Electron beam radiation

Antibodies

Interferon

Histone Deacytelase inhibitors

61
Q

Adult Tcell lymphoma/Leukemia is caused by

A

HTLV

62
Q

Mode of transmission of HTLV1

A

Placental

breast feeding

Blood transfusion

Sexual transmission

63
Q

Latency for different diseases due to HTLV infection

A

T cell lymphoma: 55 years

Tropical spastic paraparesis: 1-3 years

64
Q

Peripheral blood picture in T cell lymphoma

A

Flower cells

65
Q
A

Flower cells

T cell leukemia

66
Q

CD in T cell lymphoma

A

CD2,CD3,CD4,CD5,CD25

67
Q

Treatment of T cell Lymphoma

A

Interferon

Zidovudine

Arsenic trioxide

68
Q

Bone marrow involvement in Adult T cell lymphoma/Leukemia

A

Usually not involved

Anemia and thrombocytopenia are uncommon

69
Q

lung lesions in Adult T cell leukemia are due to

A

Tumor infiltration

Infection

70
Q

Markers of anaplastic large T/null cell lymphoma

A

CD30(Ki antigen)

ALK protein

t(2;5)

71
Q

ALK inhibitor

A

Crizotinib

72
Q

Aggressive lymphoma with good prognosis

A

anaplastic large T/null cell lymphoma

73
Q

Presentation of angioimmunoblastic T cell lymphoma

A

Generalised lymphadenopathy

Fever

Skin rash

Weight loss

Polyclonal hypergammaglobulinemia

74
Q

Synonyms for extranodal T/NK cell lymphoma of nasal type

A

Angiocentric lymphoma

Lethal midline granuloma

75
Q

Lymphoma that occurs in untreated gluten sensitive enteropathy patients

A

Enteropathy type intestinal T cell lymphoma

76
Q

Hemophagocytic syndrome is common in which lymphomas

A

Extranodal T/NK cell lymphoma of nasal type

Subcutaneous panniculitis-like T cell lymphoma

77
Q

Presentation of hodgkin lymphoma

A

Painless lymphadenopathy of neck,supraclavicular area and axilla

mediastinal adenopathy

78
Q

Hodgkin presenting with subdiaphragmatic involvement is seen in

A

older males

79
Q

Fever pattern in hodgkin

A

Pel ebstein fever

80
Q

Unusual manifestations of hodgkin disease

A

Severe unexplained itching

Erythema nodosum

Ichthyosiform atrophy

paraneoplastic cerebellar degeneration

nephrotic syndrome

autoimmune hemolytic anemia

thrombocytopenia

pain in nodes on alcohol consumption

Hypercalcemia

81
Q

In whom hodgkin presents as FUO?

A

Older patients with mixed cellularity hodgkin in abdominal site

82
Q

Most common subtype of hodgkin in US

A

Nodular sclerosing

83
Q

Hodgkin subtypes seen in PLHA

A

Mixed cellularity

lymphocyte depleted

84
Q

DD for hodgkin disease

A

Inflammation

Phenytoin

NHL

Mononucleosis

Nonlymphomatous malignancies

85
Q
A

Hodgkin disease-mixed cellularity

86
Q

In hodgkin PET and gallium scans are useful for

A

documenting remission

87
Q

Chemotherapy regimens in Hodgkin

A

ABVD

MOPP

Stanford V

BEACOPP

88
Q

ABVD

A

doxorubicin, bleomycin, vinblastine, and dacarbazine

89
Q

MOPP

A

mechlorethamine, vincristine, procarbazine, and prednisone

90
Q

Stanford V

A

A mustard derivative such as Cyclophosphamide, Mechlorethamine or Ifosfamide
Doxorubicin
Vinblastine
Vincristine
Bleomycin
Etoposide
Prednisone

91
Q

BEACOPP

A

Bleomycin

Etoposide

Doxorubicin

Cyclophosphamide

Vincristine

Procarbazine

Prednisone

92
Q

Late Rx side effects in hodgkin

A

Leukemia(common in MOPP)

Breast cancer,Lung cancer(Thoracic radiotherapy)

Stroke(cervical radiation)

CAD(Thoracic radiotherapy)

Hypothyroidism

Lhermitte syndrome

Infertility

93
Q

Immunophenotype of nodular lymphocyte predominant hodgkin disease

A

CD45+

EMA+(Epithelial membrane antigen)

CD15-

CD30-

94
Q

Causes of reactive lymphoid hyperplasia

A

Phenytoin,Carbamazepine

RA

SLE

CMV,EBV

Cat scratch disease

95
Q

Presentation of disseminated castleman

A

Lymphadenopathy

anemia

polyclonal hypergammaglobulinemia

96
Q

Manifestations of disseminated castleman is due to

A

IL-6

97
Q

Rosai dorfman disease

A

Sinus histiocytosis with massive lymphadenopathy

AIHA

98
Q

Lymphoma that can lead to intestinal perforation

A

Enteropathy type intestinal T cell lymphoma

Hematology (9 decks)

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