Cutaneous T cell lymphoma(medscape) Flashcards
Cutaneous T cell lymphoma is a type of
NHL
Distribution of patches in mycosis fungoides
bikini area
lower trunk and buttocks
Plaque phase of mycosis fungoides
intensly pruritic
Lymphadenopathy
Tumors in MF
prone to ulceration
Sezary syndrome,clinical presentation
edematous skin
lymphadenopathy
hepatosplenomegaly
palmoplantar hyperkeratosis
alopecia
nail dystrophy
ectropion
Minimum amount of sezary cells required for diagnosis
>1000 cells/µL
Immunophenotypic abnormalities in sezary syndrome
CD4/CD8 ratio of more than 10
Loss of any or all of T cell antigens CD2,CD3,CD4,CD5
Second most common extranodal site for lymphomas
Skin
primary cutaneous Cd30 positive lymphoproliferative disorders
Anaplastic large cell lymphoma cutaneous type(ALK negative)
lymphomatoid papulosis
Difference between cutaneous and systemic anaplastic large cell lymphoma
absence of t(2;5) in cutaneous form
Size of lymphomatoid papulosis
<2cm
20% of Lymphomatoid papulosis may evolve into
HD
Cutaneous anaplastic large cell lymphoma
MF
Cd of subcutaneous panniculitis like T cell lymphoma
CD8+ CD3+