Male reproductive system Histology Flashcards
Label the structures of the testes
- site of sperm production
- site of endocrine glands
- testosterone synthesis, storage and secretion
- structure
- oval, 4cm long and 3cm thick
- layers
-
tunica albuginea
- dense irregular collagenous connecitve tissue capsule
- each teste has its own tunica albuginea
-
mediastinum testes
- thickened posterior portion of tunica albuginea
- possess rete testis
- a series of spaces that act as a conduit for passage of sperm
-
tunica albuginea
What is the dense irregular collagenous connnective tissue capsule that envelopes each teste?
- site of sperm production
- site of endocrine glands
- testosterone synthesis, storage and secretion
- structure
- oval, 4cm long and 3cm thick
- layers
-
tunica albuginea
- dense irregular collagenous connecitve tissue capsule
- each teste has its own tunica albuginea
-
mediastinum testes
- thickened posterior portion of tunica albuginea
- possess rete testis
- a series of spaces that act as a conduit for passage of sperm
-
tunica albuginea
series of spaces that act as a conduit for passage of sperm. Describe the route from synthesis-> vas deferens.
- site of sperm production
- site of endocrine glands
- testosterone synthesis, storage and secretion
- structure
- oval, 4cm long and 3cm thick
- layers
-
tunica albuginea
- dense irregular collagenous connecitve tissue capsule
- each teste has its own tunica albuginea
-
mediastinum testes
- thickened posterior portion of tunica albuginea
- possess rete testis
- a series of spaces that act as a conduit for passage of sperm
-
tunica albuginea
250 of these are found in each testes. subdivisions of connective tissue septa that radiate from the mediastinum testis
testes with seminiferous tubules
-
testicular lobules
- each testes has ~250 lobules
- subdivisions of testes formed of connective tissue septa that radiate from mediastinum testis
- seminferous tubules
- fill each lobule and are the site of spermatozoa production
- each lobule may have 1-4 seminiferous tubules
- myeloid cells and fibroblasts
- present in the connective tissue wall of each seminiferous tubule
fill each testicular lobule and are the site of spermatozoa production
testes with seminiferous tubules
- testicular lobules
- each testes has ~250 lobules
- subdivisions of testes formed of connective tissue septa that radiate from mediastinum testis
-
seminferous tubules
- fill each lobule and are the site of spermatozoa production
- each lobule may have 1-4 seminiferous tubules
- myeloid cells and fibroblasts
- present in the connective tissue wall of each seminiferous tubule
present in the connective tissue wall of each seminiferous tubule
testes with seminiferous tubules
- testicular lobules
- each testes has ~250 lobules
- subdivisions of testes formed of connective tissue septa that radiate from mediastinum testis
- seminferous tubules
- fill each lobule and are the site of spermatozoa production
- each lobule may have 1-4 seminiferous tubules
-
myeloid cells and fibroblasts
- present in the connective tissue wall of each seminiferous tubule
What is seen, with respect to layers, with a cross section of the seminiferous tubule?
- seminiferous epithelium is responsible for sperm production
- when a seminiferoud tubule is viewed in cross section, developing germ cells are arranged in different stages of development
- youngest cells
- developmental lineage comprise the basal layer of cells (outermost layer)
- mature germ cells
- in the luminal compartment of the tubule
- nearest the center
- in the luminal compartment of the tubule
- youngest cells
Explain the outermost layer of cells in the seminiferous tubule.
- seminiferous epithelium is responsible for sperm production
- when a seminiferoud tubule is viewed in cross section, developing germ cells are arranged in different stages of development
-
youngest cells
- developmental lineage comprise the basal layer of cells (outermost layer)
- mature germ cells
- in the luminal compartment of the tubule
- nearest the center
- in the luminal compartment of the tubule
-
youngest cells
What type of germ cells are in the ad luminal compartment?
- seminiferous epithelium is responsible for sperm production
- when a seminiferoud tubule is viewed in cross section, developing germ cells are arranged in different stages of development
- youngest cells
- developmental lineage comprise the basal layer of cells (outermost layer)
-
mature germ cells
-
in the luminal compartment of the tubule
- nearest the center
-
in the luminal compartment of the tubule
- youngest cells
what are the phases of spermatogenesis? Describe them
- spermatogenesis
- process by which mature spermatozoa are formed from the immature diploid spermatogonia
-
divided into three phases, during which different sybtypes are formed as cells undergo mitosis
-
spermatocytogenesis
- formation of primary spermaocyes via differentiation and mitosis of spermatogonia
-
meiosis
- reduction division of diploid spermatocytes resulting in haploid spermatids (both number and DNA content)
-
differentiation or spermiogenesis
- an elaborate differentiation process whereby mature spermatozoa are formed from spermatids NO CELL DIVISIONS ARE INVOLVED
-
spermatocytogenesis
process by which mature spermatozoa are formed from the immature diploid spermatogonia
-
spermatogenesis
- process by which mature spermatozoa are formed from the immature diploid spermatogonia
- divided into three phases, during which different sybtypes are formed as cells undergo mitosis
- spermatocytogenesis
- meiosis
- differentiation or spermiogenesis
formation of primary spermatocytes via differentiation and mitosis of spermatogonia
-
spermatocytogenesis
- formation of primary spermatocytes via differentiation and mitosis of spermatogonia
- SPERMATOGONIA
- first cells in the sperm lineage- two types. Have diploid number of chromosomes and tetraploid DNA content. Adjacent to basal lamina with a rounded shape.
- types
- A
- mitotic stem cells of sperm lineage
- divide to give rise to more type A or type B spermatagonia
- have a slightly flattened or oval nucleus that varies in staining
- B
- undergo mitosis to give rise to primary spermatocytes
- have rounded nucleus
- A
- primary spermatocytes
- diploid cells formed form mitosis of type B spermatogonia
- these cells have the largest nucleus of any cells in sperm lineage
- migrate from the basal compartment towards the ad luminal compartment with in a seminiferous tubule.
describe the two types of spermatogaonia and the relationship between the two.
- spermatocytogenesis
- formation of primary spermatocytes via differentiation and mitosis of spermatogonia
- SPERMATOGONIA
- first cells in the sperm lineage- two types. Have diploid number of chromosomes and tetraploid DNA content. Adjacent to basal lamina with a rounded shape.
-
types
-
A
- mitotic stem cells of sperm lineage
- divide to give rise to more type A or type B spermatagonia
- have a slightly flattened or oval nucleus that varies in staining
-
B
- undergo mitosis to give rise to primary spermatocytes
- have rounded nucleus
-
A
- primary spermatocytes
- diploid cells formed form mitosis of type B spermatogonia
- these cells have the largest nucleus of any cells in sperm lineage
- migrate from the basal compartment towards the ad luminal compartment with in a seminiferous tubule.
formed from B spermatogonia. Describe them and their migration.
- spermatocytogenesis
- formation of primary spermatocytes via differentiation and mitosis of spermatogonia
- SPERMATOGONIA
- first cells in the sperm lineage- two types. Have diploid number of chromosomes and tetraploid DNA content. Adjacent to basal lamina with a rounded shape.
- types
- A
- mitotic stem cells of sperm lineage
- divide to give rise to more type A or type B spermatagonia
- have a slightly flattened or oval nucleus that varies in staining
- B
- undergo mitosis to give rise to primary spermatocytes
- have rounded nucleus
- A
-
primary spermatocytes
- diploid cells formed form mitosis of type B spermatogonia
- these cells have the largest nucleus of any cells in sperm lineage
- migrate from the basal compartment towards the ad luminal compartment with in a seminiferous tubule.
reductiton division of diploid spermatocytes resulting in haploid spermatids (both number and DNA content). What are the divisions?
-
meiosis
- reductiton division of diploid spermatocytes resulting in haploid spermatids (both number and DNA content)
- first meitotic division
- secondary spermatocytes
- formed when primary spermatocytes undergo the 1st meitotic division.
- These cells have a notably smaller nucleus than primary seprmatocytes
- 1st meiotic division results in halving of the chromosomes per cell to haploid (1N) number
- DNA contenct is 2N
- Secondary spermatocytes enter into the 2nd meitotic division almost immediatly after they are formed
- very few are seen in the histological sections
- secondary spermatocytes
- second meiotc division
- spermatids
- formed from the 2nd meiotic division of secondary spermatocytes
- have a haploid number of both chromosomes and DNA content
- eary spermatids are small round cells
- spermatids
these spermatocytes are hard to see because the division is very rapid.
- what is their ploidy
- meiosis
- reductiton division of diploid spermatocytes resulting in haploid spermatids (both number and DNA content)
- first meitotic division
- secondary spermatocytes
- formed when primary spermatocytes undergo the 1st meitotic division.
- These cells have a notably smaller nucleus than primary seprmatocytes
- 1st meiotic division results in halving of the chromosomes per cell to haploid (1N) number
- DNA contenct is 2N
- Secondary spermatocytes enter into the 2nd meitotic division almost immediatly after they are formed
- very few are seen in the histological sections
- secondary spermatocytes
- second meiotc division
- spermatids
- formed from the 2nd meiotic division of secondary spermatocytes
- have a haploid number of both chromosomes and DNA content
- eary spermatids are small round cells
- spermatids
Spermatids are found in which division of spermatogenesis? describe the ploidy and structure
- meiosis
- reductiton division of diploid spermatocytes resulting in haploid spermatids (both number and DNA content)
- first meitotic division
- secondary spermatocytes
- formed when primary spermatocytes undergo the 1st meitotic division.
- These cells have a notably smaller nucleus than primary seprmatocytes
- 1st meiotic division results in halving of the chromosomes per cell to haploid (1N) number
- DNA contenct is 2N
- Secondary spermatocytes enter into the 2nd meitotic division almost immediatly after they are formed
- very few are seen in the histological sections
- secondary spermatocytes
-
second meiotc division
-
spermatids
- formed from the 2nd meiotic division of secondary spermatocytes
- have a haploid number of both chromosomes and DNA content
- eary spermatids are small round cells
-
spermatids
an elaborate differentiation process wherby mature spermatozoa are formed from spermatids Is there cell division involved?
-
spermiogenesis
- an elaborate differentiation process wherby mature spermatozoa are formed from spermatids
- NO CELL DIVISIONS ARE INVOLVED
- early spermatids morphology
- typical small cell
- undergoes drastic morphological changes as it proceeds through spermiogenesis and reaches late spermatid stage
- cells are considered spermatids as long as they remain attached to sertoli cells, even thoug hlate spermatids have the morphology of a spermatozoa.
descrie the product in spermiogenesis. What are these cells attached to?
- spermiogenesis
- an elaborate differentiation process wherby mature spermatozoa are formed from spermatids
- NO CELL DIVISIONS ARE INVOLVED
-
early spermatids morphology
- typical small cell
- undergoes drastic morphological changes as it proceeds through spermiogenesis and reaches late spermatid stage
- cells are considered spermatids as long as they remain attached to sertoli cells, even though late spermatids have the morphology of a spermatozoa.
describe the major events in spermiogenesis
- acromosome formation
- 3 other main events
major events in spermiogenesis
- acrosome formation
- numerous small pre-acrosomal granules are formed early in spermiogenesis.
- membrane bound vesicles contain
- hydrolytic enzymes formed in the rER and modified in the golgi
- acrosomal vesicle
- formed by the fusion of pre-acrosomal granules
- acrosome (acrosomal cap)
- forms from the acrosomal vesicle after it enlarges and migrates to the anterior pole of the sperm, covering or “capping” the nucleus
- acrosome function
- facilitates fertilization
- enzymes contained in the acrosomes separate tha cells of tocum’s corona radiata and penetrate zona pellucida
- condensation of nuclear material
- flagellum formation
- principal piece
- forms from a centriole that migrates to the posterior of the nucleus
- middle piece
- the thickened proximal portion of the flagellum, interspersed between the sperm head and principal piece
- mitochondria aggregate in this region
- flagellar motion is generated in this region
- principal piece
- shedding of excess cytoplasm
- residual bodies
- mature but not yet function sperm are released into the lumen of the seminferous tubule
Describre the formation, structure and function of the acrosome
major events in spermiogenesis
-
acrosome formation
- numerous small pre-acrosomal granules are formed early in spermiogenesis.
-
membrane bound vesicles contain
- hydrolytic enzymes formed in the rER and modified in the golgi
-
acrosomal vesicle
- formed by the fusion of pre-acrosomal granules
-
acrosome (acrosomal cap)
- forms from the acrosomal vesicle after it enlarges and migrates to the anterior pole of the sperm, covering or “capping” the nucleus
-
acrosome function
- facilitates fertilization
- enzymes contained in the acrosomes separate tha cells of tocum’s corona radiata and penetrate zona pellucida
- condensation of nuclear material
- flagellum formation
- principal piece
- forms from a centriole that migrates to the posterior of the nucleus
- middle piece
- the thickened proximal portion of the flagellum, interspersed between the sperm head and principal piece
- mitochondria aggregate in this region
- flagellar motion is generated in this region
- principal piece
- shedding of excess cytoplasm
- residual bodies
- mature but not yet function sperm are released into the lumen of the seminferous tubule