Male Repro phys

Question 1

what stimulates T production by leydig cells in fetal development? At what point does this occur?

Answer 1

hCG stimulates leydig cells to produce T

begins at ~8wks

Question 2

Wolffian duct produces

Answer 2

epididimis
vas deferens
seminal vesicle
after T stimulation

Question 3

Urogenital sinus produces

Answer 3

prostate and bulbourethral gland after DHT stimulation (912 wks)

Question 4

The genital tubercle becomes…

Answer 4

the CC and CS and glans after DHT stimulation (9-12wks)

Question 5

5α-reductase-2

Answer 5

expressed in peripheral tissues (UG sinus, skin, hair follicles, liver)
stimulates prostate, penile, scrotal, pubic hair, and muscle mass growth

Question 6

5α-reductase-1

Answer 6

found in skin

causes sebaceous gland activity and acne during puberty

Question 7

Deficiency of 5α-reductase-2

Answer 7

ambiguous external genitalia

Question 8

Inhibin B

Answer 8

produced by sertoli cells to inhibit GSH (T, DHT, E all inhiiibit LH)

Question 9

Products of sertoli cells

Answer 9

ABP
E2
Growth factors 
Inhibin B
\_\_\_\_\_\_\_\_\_\_
Produces AMH
spermiation 
maintains BTB

Question 10

levels of T during fetal development

Answer 10

HIGH T

low LH

Question 11

T and LH levels during developent

Answer 11

T is high in fetal life, and immediately after birth
both fall dramatically in childhood and then rise steadily during puberty
T will decline during old age (60%!)