Male Pathology Syndromes: Gupta Flashcards
Hypospadia and Epispadia
in the male it’s an abnormal development of the urethra:
hypospadia - opens to ventral aspect of penis
epispadia - opens to dorsal aspect of penis
Balanitis and Balanoposthitis;
Causes
Balanitis = inflammation of the glans penis
Balanoposthitis = inflammation of the overlying prepuce (foreskin)
Causes include candida, anaerobes, gardnerella, pyogenic bacteria
*Most cases occur as a consequence of poor local hygiene in uncircumscised males
Phimosis
a condition in which the prepuce cannot be retracted easily over the glans penis; can be normal but becomes pathologic when interfering with normal function
Squamous cell carcinoma of the penis
- assoc’d with HPV infection and most cases occur in uncircumcised males
- ulceration on the glans or shaft of penis
- can spread to inguinal nodes and rarely to distant sites
Cryptorchidism
- failure of testicular descent from the abdomen into the scrotum
- unknown cause
- assoc’d with 3-5 fold inc. risk of testicular cancer
Testicular atrophy
testes diminish in size and may be accompanied by loss of function
Inflammatory lesions of the testes
- more common in the epididymis
- can be caused by UTI spread through the vas deferens, mumps infection (20% adult males, rarely in kids), or TB
- UTI spread - NT infiltrate
- mumps - lymphoplasmacytic inflammatory infiltrate
- TB - granulomatous infiltration and caseous necrosis
Testicular torsionw
- the obstruction of testicular venous drainage leaving the arteries patent; this is a urologic emergency because there’s about 6hrs to fix it or the testes may not remain viable
- neonatal = in utero or shortly after birth
- adult = sudden onset of pain where there’s an anatomic defect allowing for increased motility
Seminoma
in testes
- a malignant germ cell tumor of the testicles; may or may not have syncytiotrophoblasts but that doesn’t affect prognosis
- 40-50yo’s
- will see sheets of polygonal cells with LCs in the stroma
Embryonal carcinoma
in testes
- malignant tumor of undifferentiated cells and primitive gland-like structures
- nuclei are large and hyperchromatic
- primary can be small but metastatic and pure cases are rare, typically mixed cell types
Yolk sac tumor
in testes
- tumors often have eosinophilic hyaline globules in which alpha-1-antitrypsin and AFP can be demonstrated
- contain Schiller-Duval bodies
- often children
Choriocarcinoma
in testes
- tumor contains cytotrophoblastic (central nuclei) and syncytiotrophoblastic cells (multiple dark nuclei embedded in eosinophilic cytoplasm)
- hemorrhage and necrosis are prominent
Teratoma
in testes
- germ cell tumor which can have mature or immature elements
- pure teratomas are second only in frequency to yolk sac tumors in kids
- can occur at any age but in pre-pubertal males - usually benign; if in post-pubertal males usually malignant
3 Major conditions of the prostate
- Prostatitis
- BPH/Nodular Hyperplasia
- Carcinoma
Prostatitis
bacterial infection of the prostate, most common organism is E. coli or another Gram-neg rod; may be chronic or acute; will have NT infiltration of the prostate