HPV: Ryan

Question 1

Describe the HPV serotypes associated with benign anogenital warts and those at high risk for transformation to cancer.

Answer 1

HPV 6 and 11 benign

HPV 16 and 18 high risk for cancer

Question 2

What are the two viral proteins responsible for binding and ultimately removing or inactivating two tumor suppressor proteins p53 and RB?

Answer 2

E6 and E7

Question 3

Is the cancer associated with HPV derived from permissive or non-permissive cells? Explain why.

Answer 3

Non-permissive. Late gene expression does not occur, and instead of virus production, infxn leads to the transformation of cells.

Question 4

Explain how warts form.

Answer 4

Virus infects cells in the germinal cells in the basal layer of the epidermis. These cells are non-permissive and are transformed. As they move to the surface of the skin, they become permissive and shed virus (hence the contagion). These transformed cells replicate as a tumor and form the wart.

Question 5

Describe the DNA and structure of the HPV.

Answer 5

Circular, double-stranded DNA genome.

Non-enveloped icosahedral capsid.

Question 6

What’s going on in laryngeal papillomas?

Answer 6

chronic, benign warts that appear in the respiratory tract, usually before the age of 5. They are rare but can block the tract, proving fatal.