Male Genital System

Question 1

Neoplasms of the Penis (three)

Answer 1

1. Condyloma Acuminatum
2. Carcinoma in situ of the Penis
3. Squamous cell carcinoma of the penis

Question 2

Condyloma Acuminatum

-how to remember

Answer 2

Acuminatum…Accumulation…Outgrowths

otherwise known as genital warts

Question 3

Condyloma Acuminatum

• cause
• benign or malignant
• histopathology

Answer 3

cause
-caused by low risk types of HPV (6 and 11)
Benign or malignant?
-Benign, rarely progresses to in situ or invasive cancers
histopathology
-epithelium may have superficial hyperkeratosis and thicker underlying epidermis

Question 4

Carcinoma in situ of the penis

-two types

Answer 4

1. Bowens Disease

2. Bowenoid Papulosis

Question 5

Carcinoma in situ of the penis: Bowens Disease

• cause
• histopathology

Answer 5

cause
-things getting riskier so cause is more dangerous type of HPV (16)
histopathology
-chewing also risk and the plaques are red and white like types of -plakia
-USUALLY A SINGLE LESION IN BOWENS DISEASE
-White plaque (seen more often)
-Red plaque: erythroplasia of Queyrat

Question 6

Carcinoma in situ of the penis: Bowenoid Papulosis

Answer 6

• Bowen was singular, papulosis is plural so multiple lesions
• but never develops into invasive carcinoma

Question 7

Squamous cell carcinoma of the penis

• Where
• Histopathology
• Clinical

Answer 7

Where:
-it is a squamous cell carcinoma so manifests in skin kinds of places (glans and foreskin)
histopathology:

Gross:

• Squamous…qu…queer…gay…gray
• leasions are gray

microscopic:
-lesion is keratinizing with infiltrating margins

clinical:
-lesions are painless

Question 8

cryptochordism

Answer 8

undescended testis

-can be bilateral or unilateral

Germ cells are in arrested development

• germ cells buried, temp too hot so they die off
• Leydig cells compensate by multiplying*

*reason why these patients have a 3-5x greater risk of testicular cancer even after surgical correction

Question 9

Seminoma

• what is it
• how to remember

Answer 9

• oma, so tumor
• semi-, so halfway or sorta underdeveloped (like germ cells

This is a germ cell tumor (lance armstrong) in the testis

Question 10

Seminoma

• Dx
• Clinical

Answer 10

Dx:
-25% of cases will stain positive for hCG

Clinical:

• Rapidly growing, so really sensitive to radiation
• 90% cure rate (Lance Armstrong beat it)

Question 11

Prostatitis

-Two types

Answer 11

Acute and chronic

Question 12

Acute prostatitis

• cause
• characteristics

Answer 12

cause:
-UTI bacteria

Characteristics (stuff would associate with an acute Bacterial infection):

• neutrophil inflammatory infiltrate
• congestion
• Edema
• Larger Prostate

Question 13

Chronic prostatitis

• cause
• characteristics

Answer 13

Cause: chronic injury

characteristics:

• Gland has undergone chronic injury so there’s a lymphoid (B and T) infiltrate
• tissue destruction
• inflammatory cells

Question 14

prostatitis

-clinical (for both types)

Answer 14

Clinical:

• Dysuria
• frequency
• lower back pain
• diffuse pelvic pain

*chronic prostatitis may be symptomatic or silent

Question 15

Benign Prostate Hyperplasia

• Location
• Histopathology
• Clinical

Answer 15

Location:
-transitional and central zones

Histopathology:
-because of location, hyperplastic elements are glands or have glandular and fibrostromal elements

clinical:
-urethra compressed, difficulty in passing urine

Question 16

Prostate Cancer:

• Location
• Dx
• Metastasis

Answer 16

location:
-peripheral zone (periphery more vulnerable to dangerous stuff)

Dx:
-PSA: not specific, but useful for recurrence detection

Metastasis:
-Bone (remember from anatomy)