malaria

Question 1

Only listed drug that works during liver phase

Answer 1

Atovacone-proguanil (Malarone)

Question 2

Drug of Choice - even for kids and pregos

Answer 2

Chloroquine (Aralen)

Question 3

Major side effect of Chloroquine that is more apparent in dark skinned patients

Answer 3

PRURITIS (also nausea, vomitting, abdominal pain, headaches)

Question 4

First line for CQ resistance (or unknown resistance)

Answer 4

Atovacone-proguanil (Malarone)

Question 5

Protein-bound P450 inducer

Answer 5

Atovacone-proguanil (Malarone)

Question 6

Tetracycline reduces plasma concentration by 40%

Answer 6

Atovacone-proguanil (Malarone)

Question 7

New, derived from Chinese herb and works on Gametocyte phase

Answer 7

Arteminisins

Question 8

ADRs for Arteminisins

Answer 8

1. Neurological changes
2. Decreased neutrophils
3. Increased liver enzymes

Question 9

Primarily used as post-exposure prophylaxis and radical cure for P. vivax and P. ovale

Answer 9

Primaquine

Question 10

Before using this drug, must check G6PD levels

Answer 10

Primaquine

Question 11

Fatal dose of Quinine

Answer 11

2.8g (cinchonism) from Long QT

Question 12

ADRs of Quinine

Answer 12

tinnitus, visual disturbances, headache, dysphoria
hypoglycemia, hypotension
long QT

Question 13

most effective for preventing P. vivax

Answer 13

Primaquine