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SFoM > Major GAGs > Flashcards

Major GAGs Flashcards

1
Q

Hyaluronan

A

Glucoronic acid + GlcNac

(No SO3)

Major component of aggregan proteogylcans
Not covalently attached to proteins
Found in bacteria
Lubricant and shock absorber
In synovial fluid (joints), loose connective tissue, cartilage

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2
Q

Dermatan sulfate

A

Iduronic acid + GalNac

Skin, blood vessels, heart valves

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3
Q

Chondroitin sulfate

A

Glucuronic acid + GalNac

Most abundant GAG
Cartilage, tendons, ligaments, aorta
Noncovalent I/a with hyaluronic acid
Bind collagen in cartilage making fibers a tight network

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4
Q

Keratan sulfate

A

Galactose + GlcNac

No acidic sugar

Most diverse
KS 1 : in corneas
KS 2: in loose connective tissue with chondroiten sulfate
KS 3: in brain

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5
Q

Heparan sulfate

A

Iduronic acid + GlcNS

Heparin w/ some acetylation (less sulfate a)
Extra cellular GAG (basement membrane)

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6
Q

Heparin

A

Iduronic acid + GlcNS

Average 2.5 S per disaccharide
Intracellular in mast cells (WBCs)
Lining arteries (liver, lungs, skin)
Anticoagulant

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SFoM (10 decks)

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