MAJOR EXAM 1 Flashcards
The heterophile antibody test is reported as_
a. Lowest dilution that shows hemolysis
b. Lowest dilution that shows agglutination
c. Highest dilution that shows hemolysis
d. Highest dilution that shows agglutination
Highest dilution that shows agglutination
The forsman heterophile antibody found in normal serum is adsorbed by —
a. Beef red cell
b. Guinea pig kidney antigen
c. Monkey kidney cell
d. Sheep red bloor cell
Guinea pig kidney antigen
High affinity of anti-DNA antibodies are most frequently found assoclated with
a IM
b. Scleroderma
c. Sjogren’s syndrome
d. SLE
SLE
Stain is concentrated on the edge of the nucleus is a
a. Diffuse
b. Rim
c. Speckled
d. Nucleolar
Rim
What type of antibody is represented by the homogenous pattern In FANA?
a. Anti-ds DNA
b. Anticentromere
c. Anti-ENA antibody
d. Anti-RNA antibody
Anti-ds DNA
What antibodies are represented by the nucleolar pattern in the immunofluorescence test for antinuclear antibodies?
a. Anti-histone antibodies
b. Anti-dsDNA antibodles
c. Anti-RNA antibody
d. Anticentromere
Anti-RNA antibody
Which disease is likely to show a rim pattern in Immunofluorescence microscopy test for ANA (FANA)?
a. Mixed connective tissue disease (MCTD)
b. Rheumatoid arthritis (RA)
c. Systemic lupus erythematosus (SLE)
d. Scleroderma
Systemic lupus erythematosus (SLE)
What disease is associated by a high titer of anti-Sm antibody?
a. MCTD
b. RA
c. SLE
d. Scleroderma
SLE
Rheumatoid factor is not found in
a. Osteoarthritis
b. Gout
c. Infectious joint disease
d. Infectious mononucleosis
Infectious mononucleosis
What is the primary class of Immunoglobulin is the serologically detectable antibody produced in rheumatoid arthritis?
a. IgA
b. IgE
C. IgG
d. IgM
IgM
Hashimoto disease is an autoimmune disease primarily involving the _
a. Kidneys
b. Liver
c. Lungs
d. Thyroid gland
Thyroid gland
An elderly woman presents with chronic fatigue, difficulty sleeping, a rapid heartbeat, and bulging eyes. Lab tests
revealed autdantibodies to thyroid-stimulating hormone. The most likely diagnosis is _
a. Hashimoto’s disease
b. Cancer of the thyrold
c. Grave’s disease
d. Pernicious anemia
Grave’s disease
An autoimmune disease causing destruction of pancreatic cells can result in_
a. Hashimoto disease
b. Multiple sclerosis
c. Myasthenia gravis
d. Type 1 Diabetes
Type 1 Diabetes
Demyelinating lesions, Increased IgG in spinal fluid and chronic relapsing occurences are characteristic of which
autoimmune disease?
a. Grave’s disease
b. Multiple sclerosis
c. Myasthenia gravis
d. Systemic lupus erythematosus
Multiple sclerosis
Goodpasture’s syndrome is characterized by glomerulonephritis in genetically susceptible Individuals. The responsible antigen is_
a. A glycoprotein dispersed uniformly on the glomerular basement mernbrane
b. A circulating antigen-antibody complex
c. Rheumatoid factor
d. A complement factor influx of neutrophils
A circulating antigen-antibody complex
What streptococcal extracellular product can dissolve fibrin clots?
a. enterotoxin
b. hyaluronidase
c. streptodornase
d. streptokinase
streptokinase
What is the endpoint for the antistreptolysin O (ASO) latex agglutination test?
a. Highest serum dilution that shows agglutination
c. Lowest serum dilution that shows agglutination
b. Highest serum dilution that shows no agglutination
d. Lowest serum dilution that shows no agglutination
Highest serum dilution that shows agglutination
False ASO results may be caused by all the following, EXCEPT:
a. Oxidation of ASO reagent
b. Room temperature reagents and specimens at the time of testing
c. Presence of beta-lipoprotein
d. Bacterial contamination
Room temperature reagents and specimens at the time of testing
Long-term complications of S. pyogenes infection include/s
a. Acute rheumatic fever
b. AGN
c. Scarlet fever
d. Both A & B only
Both A & B only
What is the positive reaction in antistreptolysin O test?
A. Agglutination
b. flocculation
c. hemolysis
d. none of the above
Agglutination
What is the serologic test of choice for diagnosing acute rheumatic fever and AGN due to S. pyogenes?
a. ASO titer
b. Anti-NADase
c. Anti-DNAse B
d. Throat culture
Anti-DNAse B
Both bacterial endocarditis and glomerlonephritis are associated with the formation of_
a. Complement system
b. Radioactive particles In blood
c. Immune complexes
d. ELISA reaction
Immune complexes
What allowed H. pylori to survive the transit through the gastric lumen to start an infection?
a. The use of antacids by a patient
b. Buffering capacity generated by the Cag A protein of the organism
c. Production of an urease enzyme
d. Presence of the polysaccharide capsule that protects the cells
Production of an urease enzyme
Most serological test for H. pylori Infection detects what antibody?
a. IgA
b. IgE
c. IgM
d. IgG
IgG
