major depressive disorder Flashcards

1
Q

major depression characteristics

A

Loss of ambition, motivation, ability to perform ADLs = Avolition

Loss of interest in usual activities (including sexual activity) & ability to experience pleasure = Anhedonia

Loss of energy = Anergia

Feelings of sadness, fear, boredom

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2
Q

major depression etiology

A

Physiological – neurotransmitter dysfunction, especially serotonin & norepinephrine

Psychological – dysfunctional coping with actual or perceived loss

New research seems to implicate the dysfunction stems from a genetic-defect which may be triggered by psychological stressors

Depression is a lethal disease with a high risk for suicide

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3
Q

3 levels of depression

A

mild

major

severe

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4
Q

mild depression

A

•usually triggered by loss -> deep sadness of limited duration

AKA grief response – can -> deeper depression if unresolved

Cognitive ∆’s = ↓alertness, ↓ability to concentrate, verbalizations of sadness

Affective ∆’s = sadness, downcast appearance, tearful

Behavioral ∆’s = social withdrawal, irritability, sleep disturbances

May use substances to “anesthetize” or diminish feelings

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5
Q

moderate depression

A

• depressive symptoms that persist over time-generally > 6 mo

Cognitive ∆’s = slowed thoughts, difficulty concentrating, indecisiveness, ruminative thoughts, narrowed interest (almost obsessive in nature), self-blame, self-doubt, pessimism

All lead to hopelessness & thoughts of suicide

Affective ∆’s = despondence, ↓self-esteem, helplessness, powerlessness, ineffectiveness, covert anger/rage, anxiety,

 anhedonia

Cognitive ∆’s = slowed thoughts, difficulty concentrating, indecisiveness, ruminative thoughts, narrowed interest (almost obsessive in nature),

self-blame, self-doubt, pessimism

All lead to hopelessness & thoughts of suicide

Affective ∆’s = despondence, ↓self-esteem, helplessness, powerlessness, ineffectiveness, covert anger/rage, anxiety,

 anhedonia

Behavioral ∆’s = social withdrawal, tears, irritability, ∆’s in oersonal hygiene, psychomotor retardation (slowing movement/speech)

Physiological ∆’s = may include HA, chest/back pain, indigestion/nausea, appetite ∆’s , ↓sexual desire, insomnia/hypersomnia/fatigue

Pt may seek Rx for physiological sx not connecting them with mood ∆’s

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6
Q

severe depression

A

•intense/pervasive/persistant manifestations of depression – life comes to a standstill

Cognitive ∆’s = confusion, inability to concentrate/make decisions – self-blame, self-deprication

Suicide is believed to be the only solution BUT pt rarely has the energy or thought clarity to organize & act on suicidal thoughts

SUICIDE RISK IS EXTREMELY HIGH WHEN ENERGY INCREASES AS DEPRESSION BEGINS TO LIFT

Affective ∆’s = despair, hopelessness, flat/blunted affect, feelings of worthlessness, guilt, isolation, loneliness – overwhelmed by any task

“bottomless emptiness”

Cognitive + Affective ∆’s = delusions of condemnation – worthlessnes, guilt, powerless to “fix” what is wrong or to atone for some “sin”

May experience auditory hallucinations = harsh sounds

Behavioral ∆’s = psychomotor activity comes to near standstill, robot-like appearance, may exhibit aimless, frantic activity i.e. pacing, pulling hair, rubbing skin – poverty of speech w/frequent pauses, low, monotonous tone of voice – pronounced inattention to personal hygiene – social withdrawal from even family & close friends

Physiological ∆’s = insomnia, sluggish digestion, constipation, anorexia, amenorrhea

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7
Q

avolition

A

inability to perform adl’s

loss of ambition, motivation

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8
Q

anhedonia

A

Loss of interest in usual activities (including sexual activity) & ability to experience pleasure

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9
Q

anergia

A

loss of energy

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10
Q

ruminative thoughts

A

same thought over and over.

broken record thoughts

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11
Q

make sure family knows

A

when patient starts to gain energy, this is when suicide risk is at the highest

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12
Q

possible nursing diagnosis of major depression

A

•Powerlessness
•Ineffective Coping
•Anticipatory or Dysfunctional Grieving
•Hopelessness
•Sleep Pattern Disturbance
•Potential for Violence – Self Directed
•Potential for Injury
•Self Care Deficit
•Anxiety
•Constipation
•Altered Nutrition

•HIGHEST PRIORITY IS ALWAYS POTENTIAL FOR VIOLENCE - SUICIDE

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13
Q

planning for major depression

A

•Establish realistic goals with pt – unrealistic goals are often unmet -> further ↓ self-esteem which then serves to rienforce worthlessness, hopelessness

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14
Q

interventions for major depression

A

•Safety
–Institute suicide precautions
–Help pt develop safety plan (both in-pt & after d/c)
•Health promotion/disease prevention
–Teach early warning signs of depression
–Help pt develop coping skills – i.e. journaling, relaxation, guided imagery, exercise
•Rest & Sleep
–Promote night-time sleeping
–Teach/promote sleep hygiene i.e. ↓caffeine, quiet/comfortable milieu
–Teach relaxation techniques
–Use hypnotics with caution
•Nutrition
–↑ fiber, ↑fluids - promote elimination
–↑ fluids – counters anti-cholinergic SE of meds
–Promote intake – favorite foods, provide safe social interaction
•Self-Care
–Assist with ADLs as necessary

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15
Q

antidepressant medications

A

•Advantage
–Can help alter withdrawal, vegetative symptoms, activity level; improve self-concept
•Drawback
–Can take 1-3+ weeks to note improvement
•Safety considerations
–Concerns about relationship between use of antidepressant drugs and suicide; however, no conclusive evidence to support this

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16
Q

tricyclic antidepressants

A

•Action: inhibit reuptake of norepinephrine and serotonin by presynaptic neurons
•Dose: start low and gradually increase
•Common adverse reactions
–Dry mouth, blurred vision, constipation, and urinary retention
–Sedation
•Potential dysrhythmias, hypotension, myocardial infarction

17
Q

SSRI’s for major depression

A

•Action: selectively block neuronal uptake of serotonin
•Common adverse reactions
–Agitation, anxiety, sleep disturbance, tremor, sexual dysfunction, headache, weight changes, nausea, diarrhea, dry mouth
•Potential toxic effect
–Serotonin syndrome (SS): potentially fatal reaction when more than one antidepressant used

18
Q

seretonin syndrome symptoms

A

–Hyperactivity, severe muscle spasms, tachycardia leading to cardiovascular shock, hyperpyrexia, hypertension, delirium, seizures, coma, death

19
Q

treatment of seretonin syndrome

A

–Stop offending agents
–Provide respiratory, circulatory support in intensive care environment
–Use medications to reverse excess serotonin: cyproheptadine, methysergide, propranolol

20
Q

atypical agents for depression

A

•Action: affect variety of NTs including those affecting serotonin and norepinephrine
•Advantage
–Can target unique populations of depressed individuals
–Can be used to treat other conditions

21
Q

MAOI’s inhibitors

A

•Action: enhance NTs at synapse by preventing the enzyme monoamine oxidase from breaking them down
•Common adverse reactions
–Hypotension, sedation, insomnia, changes in cardiac rhythm, muscle cramps, sexual impotence, anticholinergic effects, weight gain
•Potential toxic reaction
–Hypertensive crisis

22
Q

Hypertensive Crisis and MAOIs

A
  • Can occur when monoamine oxidase inhibition prevents the breakdown of tyramine, which is used by the body to make norepinephrine
  • Preventing hypertensive crisis involves maintaining a special diet (low tyramine) and avoiding medications that contain ephedrine/other psychoactive substances
23
Q

ECT

A

•Electroconvulsive therapy (ECT)
–Course of treatment: 2 or 3 treatments/week for total of 6 to 12 treatments
–For patients not responding to antidepressants or for depression with psychosis
–Potential adverse reactions
•Initial confusion and disorientation on awakening from treatment
•Memory deficits

24
Q

evaluation depression

A

•Evaluate short-term indicators and outcome criteria
–Reduction in suicidal thoughts
–Able to state alternatives to suicide
–Decrease in severity of emotional, cognitive and vegetative/physical symptoms of depression