Major Depressive Disorder Flashcards

1
Q

MDD的終生盛行率(prevalence)是多少?

A

17%

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2
Q

MDD的每年發生率(incidence,新個案)是多少?

A

1.59%

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3
Q

MDD的男女比例?

A

男比女為1:2

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4
Q

MDD onset 年齡範圍?平均年齡?近年趨勢?

A
  1. 20-50歲(50%在此區間)
  2. 40歲(事業有成後,中年危機)
  3. 小於20歲發病者越來越多
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5
Q

MDD和社經地位有關嗎?若有,是何關聯?

A

無關

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6
Q

MDD和城鄉關聯?

A

在鄉村地區較多(why?)

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7
Q

MDD和種族關聯?

A

無關

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8
Q

MDD常見的共病前四名?

A
  1. alcohol use or dependence (借酒澆愁)
  2. panic disorder (小茹發作)
  3. OCD
  4. social anxiety disorder
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9
Q

bipolar I disorder 和MDD 誰的共病比率較高?

A

bipolar, 約為MDD之兩倍

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10
Q

和MDD最相關的neurotransmitter是哪一大類? 包含哪四種?

A
  1. monoamine

2. serotonine, norepinephrine, dopamine, histamine

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11
Q

dopamine 濃度和depressive symptoms 關係?

A

濃度越低越depressed

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12
Q

目前假說認為哪條dopamine pathway和depression有關?

A

mesolimbic pathway(記:schizo正性症狀block太多後變成depression)

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13
Q

目前假說認為哪個dopamine receptor和depression有關?

A

D1 receptor (記:和schizo之D2不同)

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