Magnesium sulfate for neuroprotection

Question 1

Magnesium sulfate for neuroprotection

Answer 1

• Offer for neuroprotection of the baby to women between 24+0 and 29+6 weeks of pregnancy who are:
  
  • In established preterm labour
  • Having a planned preterm birth within 24 hours.
• Consider for neuroprotection of the baby for women between 30+0 and 33+6 weeks of pregnancy who are:
  
  • In established preterm labour
  • Having a planned preterm birth within 24 hours.

Question 2

MgSO4 regimen

Answer 2

• 4 g intravenous bolus of magnesium sulfate over 15 minutes

- Intravenous infusion of 1 g per hour until the birth or for 24 hours (whichever is sooner)

Question 3

Monitoring during MgSO4

Answer 3

• Monitor for clinical signs of magnesium toxicity at least every 4 hours by recording pulse, blood pressure, respiratory rate and deep tendon (for example, patellar) reflexes.
• If a woman has or develops oliguria or other signs of renal failure:
  
  • Monitor more frequently for magnesium toxicity
  • Think about reducing the dose of magnesium sulfate.