Magnesium Metabolism Flashcards
Is magnesium mostly intracellular or extracellular
Intracellular cation
Main function of magnesium
Stabilise excitable membrane
Percentage of magnesium filtered at glomerulus
70%
Percentage of magnesium reabsorbed at loop of henle
50-70%
Hormone that enhances magnesium réabsorption
PTH
Definition of hypomagnesemia
Concentration Below 0.75-1mmol/L
Causes of hypomagnesemia
M
Starvation
Malnutrition
Alcoholism
Parenteral alimentation
Prolonged vomiting/nasogastric aspiration
Chronic diarrhoea/laxative abuse
Malabsorption
Small bowel bypass surgery
Fistulae
Diuretic therapy
Alcohol
Tubulotoxic drugs:
Gentamicin
Cisplatin
Volume expansion
Diabetic ketoacidosis
Post-obstructive diuresis
Recovery from acute tubular necrosis
Inherited tubular transport defect:
Bartter’s syndrome
Gitelman’s syndrome
Primary renal magnesium wasting
Acute pancreatitis
Foscarnet therapy
Proton pump inhibitor therapy
Hungry bone syndrome
Diabetes mellitus