Magnesium Metabolism Flashcards

1
Q

Is magnesium mostly intracellular or extracellular

A

Intracellular cation

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2
Q

Main function of magnesium

A

Stabilise excitable membrane

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3
Q

Percentage of magnesium filtered at glomerulus

A

70%

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4
Q

Percentage of magnesium reabsorbed at loop of henle

A

50-70%

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5
Q

Hormone that enhances magnesium réabsorption

A

PTH

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6
Q

Definition of hypomagnesemia

A

Concentration Below 0.75-1mmol/L

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7
Q

Causes of hypomagnesemia

A

M
Starvation
Malnutrition
Alcoholism
Parenteral alimentation
Prolonged vomiting/nasogastric aspiration
Chronic diarrhoea/laxative abuse
Malabsorption
Small bowel bypass surgery
Fistulae
Diuretic therapy
Alcohol
Tubulotoxic drugs:
Gentamicin
Cisplatin
Volume expansion
Diabetic ketoacidosis
Post-obstructive diuresis
Recovery from acute tubular necrosis
Inherited tubular transport defect:
Bartter’s syndrome
Gitelman’s syndrome
Primary renal magnesium wasting
Acute pancreatitis
Foscarnet therapy
Proton pump inhibitor therapy
Hungry bone syndrome
Diabetes mellitus

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