Macrovascular complications of diabetes

Question 1

What leads to atheroma?

Answer 1

Small accumulations of extracellular lipid

Question 2

What sort of disease causes people with diabetes to die?

Answer 2

Macrovascular- causes mortality and morbidity whereas microvascular just causes morbidity

Question 3

What is the Framingham risk score?

Answer 3

Gender-specific algorithm used to estimate the 10-year cardiovascular risk of an individual

Question 4

What ethnicity has an increased risk of coronary heart disease?

Answer 4

South Asians

Question 5

What is the major cause of morbidity and mortality in diabetes?

Answer 5

Ischaemic heart disease

Question 6

What are the other major forms of macrovascular disease?

Answer 6

Cerebrovascular disease
Peripheral vascular disease
Renal artery stenosis

Question 7

How does intensive glucose treatment affect the risk of cardiovascular disease?

Answer 7

Not significantly- it does improve CHD risk but doesn’t change much in terms of mortality

Question 8

How do you manage macrovascular disease?

Answer 8

Aggressive management of risk factors (bp and cholesterol):
Dyslipidaemia 
High blood pressure
Smoking 
Diabetes

Question 9

What specific treatment significantly reduces macrovascular disease risk?

Answer 9

Statins