Machines And +- Flashcards

1
Q

Disadvantages of urine sampling (4)

A
  1. Observed collection can be seen as an infringement of privacy
  2. Difficult to interpret
  3. Mostly metabolites
  4. Easily adulterated
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2
Q

Advantages of Urine Sampling (5)

A
  1. Easy to collect and analyse
  2. Large volumes available
  3. Inexpensive
  4. Can be screened directly
  5. History of drug use can be seen
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3
Q

Advantages of Blood sampling (3)

A
  1. Indicates recent use
  2. Hard to adulterated
  3. Easily interpreted
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4
Q

Disadvantages of blood sampling (4)

A
  1. Requires trained personnel to collect
  2. Low concentrations of drugs
  3. Requires specialised lab
  4. Costly
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5
Q

Advantages of sweat sampling (2)

A
  1. Non-invasive

2. Easy to collect

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6
Q

Disadvantages of sweat sampling (3)

A
  1. Not widely used
  2. Expensive
  3. Difficult to interpret
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7
Q

Advantages of saliva sampling (4)

A
  1. Easy to collect
  2. Tested on site
  3. Hard to adulterate
  4. Recent use for non-smoked drugs
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8
Q

Disadvantages to saliva sampling (3)

A
  1. Limited sample size
  2. Can have low concentrations
  3. Complex to interpret
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9
Q

Advantages to hair sampling (4)

A
  1. History of drug use (several months)
  2. Stable for years
  3. Non-invasive
  4. Good for heavy metals
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10
Q

Disadvantages of hair sampling (4)

A
  1. Prone to contamination
  2. Expensive to analyse
  3. Hair has to have grown for 10 days after drug use for results to be seen
  4. Limited interpretation
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11
Q

What does Dille-Koppanyi test for and what colour does it turn?

A
  • barbiturates

- purple

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12
Q

What does the Mandelin test test for and what colour does it turn?

A
  • amphetamines

- yellow

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13
Q

What does the Marquis test test for and what colour does it turn? (2)

A
  • Opiates
  • purple
  • Amphetamines
  • Dark Purple to Yellow
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14
Q

What does the Meckes test test for and what colour does it turn?

A
  • amphetamines
  • methamphetamines
  • Dark green to dark blue
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15
Q

HPLC (2)

A
  • Sample injected onto silica column

- mix separated and components detected

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16
Q

GC (3)

A
  • Sample injected onto capillary column
  • column heated to release volatile compounds
  • separated
17
Q

MS (3)

A
  • measures molecular mass
  • molecules are ionised and magnetised or electrified
  • each molecule has a characteristic decomposition pattern
18
Q

Infra-red (2)

A
  • powerful and sensitive

- ATR is good for solids and no sample prep is required