M9 Systems Microbiology Flashcards
what is the lower respiratory tract
sterile
what is a sign of poor oral health
Bacteria constantly going into bloodstream,
what does the oral population influence
rest of resp system
where would you find Group A streptococci
at back of throat
what sort of environment is the Gastro Intestinal Tract in
an Anaerobic environment
Coliforms:
Gram (-ve) organisms of GI
- E. Coli (most important)!
Ingestion:
major source of colonisation
Shedding of mucosa -
communities built up if it does not get replaced
Bile salt:
interupt fat, damage membranes
Natural flora
bacteria already in stomach, symbiotic relationship
name the viral diseases of the GI tract
- norovirus
- rotavirus
- cryptosporidium
Norovirus
(main GI infection)
aggressive, rapid transmition
Rotavirus
(acute inflammation of small intestine)
Multicellular disease of GI:
tape worm
Cryptosporidium: protozome
- Prokaryotic infections of GI:
Endogenous or Exogenous (ingested bacteria)
- E. coli, Camplylobacter, C. diff
in E.coli variants what are variants tagged by
surface pill, fimbrie, flagella
E. Coli 0157
toxin produced, damage to gut
Clostridiodes difficile
(antibiotic associated diorhoea)
- Stop predisposing antibiotic treatment!
- poor bowel flora
- 1st line treatment is Vancomycin orally
-Gram -ve spectrum, not absorbed through gut
Dysbiosis:
gut microbial factors
Antibiotic therapy:
C.difficile proliferates in absence of normal flora
disturbed gut microbiome =
weakened intestinal musodal barrier
Importance of GI Microbiome
Gut linked to ageing, cancer, autism
