M8

Question 1

In activated T-helper cells, DAG activates ………….. which act to generate the transcription factors

Answer 1

Protein Kinase C

Question 2

PIP is split by ……………. to yield DAG and IP3

Answer 2

Phospholipase C

Question 3

The co-stimulatory signal needed for complete T-helper cell activation is triggered by
interaction of ,………. on T-cells with B7 on APC

Answer 3

CD28

Question 4

Activation of T-helper cells results in the secretion of ……… leading to activation

Answer 4

IL-2

Question 5

Calcineurin ………… involved in generating the active form of the transcription factor NF-AT

Answer 5

Ca dependent enzyme

Question 6

………. is a T-cell membrane receptor that has phosphatase domains activity

Answer 6

CD45

Question 7

Fyn and Lck are …………..

Answer 7

Tyrosine kinases

Question 8

Indicate whether each of listed properties applies to T-cell receptor (TCR), B cell immunoglobulin (Ig), or both (TCR/Ig):
 Is associated with CD3 (TCR)
 MHC restricted (TCR)
 Exhibit diversity generated by isotype switching (Ig)
 Exists in membrane bound and secreted form (Ig)
 Exhibit diversity by random rearrangement of gene segments (TCR/Ig)

Answer 8

(TCR)

(TCR)

(Ig)

(Ig)

(Ig) (TCR)

Question 9

Lymphokine killer cell is activated by:
A. IL-7
B. IL-1
C. IL-2
D. Tumornecrosisfactor(TNF)

Answer 9

C

Nk is highly activated by soluble factors (Cytokines) ex: IL-2 (most famous cytokine in our bodies) and interferons.
When the IL-2 is activated, NK is then called 􏰁> lymphokine activated killer cell

Question 10

Congenital absence of the late complement components (C5, C6, C7, C8) is most often associated with:
A. Lupus-likedisease
B. Viralinfections
C. Candidiasis
D. RecurrentNeisserialinfections

Answer 10

D