M6 CCJ Neurology I Flashcards
Three types of embryological tissue
Endoderm
Mesoderm
Ectoderm
Endoderm gives rise to
Digestive Tract
Kidneys
Lungs
Mesoderm gives rise to
Circulatory system Skeletal muscle bone connective tissue genitourinary system notochord
Ectoderm gives rise to
Epidermis, hair, nails, cornea
Neural tube
Neural Crest
Neural tube gives rise to
Brain
spinal cord
motor neurons
retina
Neural crest gives rise to
Peripheral nerves
adrenal medulla
Neural tube divides into what three sections?
Prosencephalon (forebrain)
Mesencephalon (midbrain)
Rhombencephalon (hindbrain)
Prosencephalon
Forebrain
Rises from Nueral tube
Divides into Telencephalon and Diencephalon
Telencephalon
Formed from Prosencephalon
Becomes the cerebral hemispheres
Cerebral Hemispheres
Formed from Telencephalon Becomes: Cerebral cortex (gray mater) Subcortical White mater (axons) Basal ganglia Basal Forebrain Nuclei (cholinergica system - acetyl choline activation)
Diencephalon
Formed from Prosencephalon Becomes: Thalamus Hypothalamus Epithalamus
Epithalamus
Formed from diencephalon
Becomes:
Pineal gland
Roof of 3rd ventricle
Mesencephalon
Midbrain From Neural Tube Forms: Cerebral Peduncles Periaqueductal Grey Midbrain Tectum Midbrain Tegmentum
Cerebral Peduncles
Formed from Mesencephalon
Forms
Crus Cerebri
Substantia Nigra
Crus Cerebri
Part of Cerebral Peduncles
Long tracts:
Corticobulbar
Corticospinal
Substantia Nigra
Part of Cerebral Peduncles
Dopamine production
Periaqueductal Grey
From Mesencephalon
Pain inhibition
Midbrain Tectum
From Mesencephalon
Posterior to cerebral aqueduct
Superior and Inferior Colliculi
Midbrain Tegmentum
From Mesencephalon Anterior to cerebral aqueduct Made up of: Medial Lemniscus Anterolateral tracts Sup. Cerebellar Peduncles Red Nucleus CN III & IV - eye movements Raphe Nuclei Ventral Tegmental area
Medial Lemniscus
Part of Midbrain Tegmentum anterior to cerebral aqueduct
Dorsal column proprioception - ascending
Anterolateral Tracts
Part of Midbrain Tegmentum anterior to cerebral aqueduct.
Temperature, pain and crude touch - ascending
Superior Cerebellar Peduncles
Part of Midbrain Tegmentum anterior to cerebral aqueduct.
Main output of Cerebellum
Red Nucleus
Part of Midbrain Tegmentum anterior to cerebral aqueduct.
Motor coordination
Raphe Nuclei
Part of Midbrain Tegmentum anterior to cerebral aqueduct.
Serotonin Production
Ventral Tegmental Area
Part of Midbrain Tegmentum anterior to cerebral aqueduct. Dopamine production.
Serotonin
or 5-hydroxytryptamine is a monoamine neurotransmitter. It has a popular image as a contributor to feelings of well-being and happiness, though its actual biological function is complex and multifaceted, modulating cognition, reward, learning, memory, and numerous physiological processes.
Dopamine
one of the brain’s neurotransmitters—a chemical that ferries information between neurons. Dopamine helps regulate movement, attention, learning, and emotional responses. It also enables us not only to see rewards but to take action to move toward them.
Astrocyte
CNS glial cell Maintains extracellular environment Removes excess neurotransmitters Directs neural growth Induces blood-brain barrier
Satellite Cell
PNS glial cell
Maintains extracellular environment
Removes excess neurotransmitters
Directs neural growth
Oligodendrocyte
CNS glial cell
Creates myelin
Schwann Cell
PNS glial cell
Creates myelin
Microglia
CNS glial cell
Immune surveillance and phagocytosis
Ependymal Cell
CNS glial cell
Creates and circulates CSF
Unipolar Neuron
Both dendrites and axons arise form a single proccess.
Mostly in invertebrates
Bipolar Neuron
A single axon and single dendrite arise from the cell body.
Mostly sensory and involved in vision and olfaction
Multipolar Neuron
Multiple axons and dendrites arise from the cell body an/or will have axon collaterals.
Most common in mammals.
Action potential arrives at synapse
Depolarizes synaptic bulb
Synaptic bulb depolarized from action potential
Calcium ions enter the cytoplasm, and after a brief delay, ACh is released through the exocytosis of synaptic vessicles.
ACh release into synaptic cleft
ACh binds to sodium channel receptors on the postsynaptic membrane, producing a graded depolarization.
Postsynaptic depolarization
Ends as ACh is broken down into acetate and choline by AChE
ACh broken down
Synaptic knob reabsorbs choline from cleft and uses it to synthesize new molecules of ACh.
Lobes of the Cortex
Frontal Lobe
Parietal Lobe
Temporal Lobe
Occipital Lobe
Cerebral Cortex
Neocortex 2 cerebral hemispheres connected by Corpus Callosum. Conscious awareness Integration and processing 7 layers of gray matter
Frontal lobe
Executive Functioning (attention, memory, language) Social and Moral reasoning Self awareness Mood Personality Voluntary Movement (motor homunculus)
Primary Motor Cortex
Location
Frontal lobe: precentral gyrus just anterior to central sulcus
Primary Motor Cortex
Action
Contralateral voluntary motor (motor homunculus)