M5-6 Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

What are the 2 main routes of micro-organism transmission?

A

endogenous and exogenous

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What does endogenous transmission mean?

A
  • The infecting microorganisms are from from the body (own bacteria)
  • Entry into abnormal site
  • Reduced immunity
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What does exogenous transmission mean?

A
  • The infecting microorganisms are from elsewhere

- Transmitted through various mechanisms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the exogenous mechanisms through which microorganisms are transmitted?

A
  • person-to-person
  • food/water
  • vectors
  • fomites
  • vertical
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

How are microorganisms transmitted from person-to-person?

A
  • direct contact (touch)
  • contaminated blood/fluids (sexual/needles)
  • respiratory droplets/saliva
  • airborne particles
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How are microorganisms transmitted through food/water?

A
  • ingestion
  • poor sanitation - waterborne diseases
  • food poisoning
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which organisms are common vectors?

A

usually arthropods (mosquitos, flies)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are fomites? (and how are microorganisms transmitted via this route)

A

They are inanimate objects, organism survives on object and transmitted to next person

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is vertical transmission?

A

Transmitted from mother to child

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Define commensal (normal flora)

A

Lives in/on human, causes no harm, may have benefits

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are colonisers?

A

Not normally on humans, but when it is it causes harm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are pathogens?

A

May/may not normally live on human, causes harm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Describe the common commensal flora on the skin

A
  • Dry areas: mainly gram negative

- Moist areas: gram negative and positive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Describe the common commensal flora in the GIT/UGT (urogenital)

A
  • anaerobes most common
  • enteric Gram negative bacilli
  • Neisseria spp.
  • Viridans streptococci
  • Candida spp.
  • some protozoa
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Describe the common commensal flora in the URT (upper respiratory)

A
  • streptococci
  • staphylococci
  • anaerobes
  • yeasts
  • spirochaetes
  • Neisseria species
  • haemophilus
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Define pathogenicity

A

Ability of a pathogen species to cause disease

17
Q

Define virulence

A
  • Relative capacity to cause harm &often through toxins or invasion
  • Reflects the degree of pathogenicity
  • Greater virulence = severe disease and/or fewer organisms required to cause disease
18
Q

What is a virulence factor?

A

The properties that allow an organism to cause disease and influence the severity of disease

19
Q

Name the common virulence factors

A
  • Adhesion (adhesins): Pili, Receptors
  • Invasion (invasins)
  • Toxins (aggressins): Endotoxin, Exotoxin
  • Immune evasion (evasins): Capsules
20
Q

Describe how bacteria are able to overcome the normal host immune mechanisms

A

Evading phagocytosis:

  • capsules
  • phagocyte toxins
  • injects toxins into macrophage
  • inhibits phagosome
  • inhibits oxidative burst