M4: L-5 Flashcards
1
Q
What are the 5 Carboxylic acid derivatives?
A
- Carboxylic acid
- ester
- Amide (1st, 2nd, and 3rd degree)
- Acid anhydride
- Acid chloride
2
Q
What determines the relative reactivity of Carboxylic acid derivatives?
A
The size of the partial positive charge on the carbonyl carbon
3
Q
What is the order of increasing reactivity of Carboxylic acid derivatives?
A
Amide
4
Q
Why are amides the least reactive Carboxylic acid derivative?
A
They have resonance structures
5
Q
For L = OH, OR or NH2 (less reactive) reacting with a weak nucleophile, what first step allows the reaction to occur more readily and how?
A
- pronation creates a carbocation
- give nucleophile an easier target
