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Endo/Repro > M2 Repro Physio and Path > Flashcards

M2 Repro Physio and Path Flashcards

1
Q

CYP11A

A

P450 side chain cleavage for de novo steroidogenesis

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2
Q

CYP17

A

P450 hydroxylase and carboxylase for androgenesis

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3
Q

CYP19

A

P450 aromatase for estrogenesis

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4
Q

papillary carcinoma of thyroid

A

RET, BRAF
Most common, best prognosis
psammoma bodies
Orphan Annie eyes

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5
Q

follicular carcinoma of thyroid

A

RAS
Invade thyroid capsule and vasculature to spread hematogenously (usually to lung and bone)
Good prognosis

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6
Q

medullary carinoma of thyroid

A

parafollicular cells produce calcitonin leading to sheets of cells in amyloid stroma
associated with MEN 2A and 2B (RET mutation)
apple green befringence with congo red stain

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7
Q

anaplastic carcinoma of thyroid

A

most common in older patients
invades local structures to cause dysphagia, difficulty breathing
poor prognosis

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8
Q

MEN 1

A

Pituitary tumor
Pancreatic endocrine tumors
Parathyroid adenoma

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9
Q

MEN 2A

A

Parathyroid hyperplasia
Medullary thyroid carcinoma
Pheo

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10
Q

MEN 2B

A

Medullary thyroid carcinoma
Pheo
Mucosal neuroma

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Endo/Repro (7 decks)

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