M2 endo physio Flashcards
GLUT 1
Insulin independent
RBCs, brain, immune cells
GLUT 2
Insulin independent
Pancreatic beta cells, kidney, liver, intestinal cells
GLUT 3
Insulin independent
brain, placenta
GLUT 4
Insulin DEPENDENT
Skeletal muscle, cardiac muscle, adipocytes
Factors that increase insulin release
glucose ACh CCK Glucagon GLP-1 Amino Acids Ketoacids
Factors that decrease insulin release
Epi
Norepi
Somatostatin (GH)
Types of deiodinase
Type 1 (D1): makes peripheral T3 (active) and rT3 (inactive)
Type 2 (D2): peripheral and intracellular T3 (activates); removes outer ring iodine
Type 3 (D3): peripheral thyroid hormone inactivation; removes inner ring iodine
Growth factor hormone receptors
insulin, IGF-1, PRL, GH
G protein coupled receptor
Ne, E, PTH, glucagon, hypothalamic and pituitary hormones
Nuclear hormone receptor
steroid, retinoic acid, thyroid