M12 - spirochaetes Flashcards
are spirochaetes gram -ve or gram +ve
Gram -ve cell wall
where are spirochaetes commonly found?
deep periodontal pockets and numbers increase dramatically in periodontits
describe the strucutre?
helical bacteria
genus; treponema
what is lymes disease? (borreliosis)
bite by infected ticks
red spot enlarges with pale in the middle
headaches…
which bacteria is assoiciated with lymes disease?
borrelia burghdorferi
when does symtpoms begin to show?
classically 3-30 days post infection
what is congenital syphilis?
vertical transmission from mother to infant (treponema pallidum)
what is the treatment for syphilis?
penecill
list two types of oral treponemes
treponema vincentii
treponema denticola
which oral treponem is the most proteolytic member of the red complex?
t.denticola
can attach to gingival fibroblast and induce cytotoxicity and cell death
what other pathogen is T.denticola commonly found with?
P. gingivalis
define Acute necrotising ulcerative gingivitis (AUG)
An acute painful true infection of the gingivae
associated with immunosupression
which fuso-spirochaetal complex is involved?
fusobacterium nucleatum and treponema vincentii
what are the symptoms of AUG?
Acutely inflamed
bleeding
ulcers
vincents angina - unilateral sore throat
why is spirochetes mixture required?
produce different virulence factors etc
spirochaetes - production of trypsin like protease
fusobacterium spp required - provides essential growth factors
