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LAB DIAG > M1: Specific Proteins (additional) > Flashcards

M1: Specific Proteins (additional) Flashcards

0
Q

In plasma protein, 35-50g/L is

A

Albumin

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1
Q

Concentration of plasma proteins

A

65-80g/L

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2
Q

Amount of serum globulins which consist of transport proteins, reactants of acute phase & globulins

A

20-35g/L

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3
Q

How albumin is degraded

A

Hepatocytes, mononuclear phagocytic system (complexes of antigen-antibody, hemoglobin-haptoglobin.

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4
Q

Biosynthesis of plasma proteins: most responsible

A

Liver

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5
Q

Biosynthesis of plasma proteins: immunoglobulins

A

Lymphocytes

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6
Q

Types of plasma proteins

A

Albumin, Globulin & Fibrinogen

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7
Q

Protein moves in an electric field according to their charge & size

A

Electrophoresis of plasma proteins

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8
Q

Main component of the globulin which contain its bulk

A

Albumin

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9
Q

Carry fatty acids, bilirubin, calcium & drugs

A

Albumin

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10
Q

Colloidal and non diffusable and exert a coloidal osmotic preessure. Catalytic functions. Most impt in regulation of colloidal and oncotic pressure.

A

Albumin

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11
Q

Protective function which combine with foreign antigens and remove them.

A

Immunoglobulins

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12
Q

Protects the lung tissue

A

A1 antitrypsin

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13
Q

Breaks down thrombin and dissolves clot

A

Plasmin

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14
Q

Plasma proteins are mostly synthesized in the

A

Liver

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15
Q

Immunoglobulins are synthesized in the

A

Plasma cells

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16
Q

Exception as glycoprotein

A

Albumin

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17
Q

Conditions like cell destruction, reversible cell damage & metabolic activation

A

Acute Phase Reactants

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18
Q

Fraction that migrates in a position faster than albumin toward the anode. Tetrameric structure with a total MW of 62000 Da, each monomer can bind a molecule of thyroxine.

A

Prealbumin

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19
Q

Small fraction of thyroxine is bound to TBPA because TBG has 100x greater affinity for thyroxine.

A

Transthyretin/TBPA (TTR)

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20
Q

Role in metabolism in Vitamin which form a complex with RBP. Rich in tryptophan. Short half life 2 days.

A

Pre albumin

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21
Q

Disease affecting pre albumin

A

Type I Familial Amyloidotic Polyneuropathy

22
Q

2/3 of total protein. Mobile repository of AA for incorporation into other proteins.

23
Q

Biosynthesis of plasma proteins:

A

Analbuminemia

24
Q

Major component of the a1-globulins is the protease inhibitor AAT combine with and inactive trypsin

A

A1 antitrypsin

25
Q

Released following inflammation responding to irritants

26
Q

Best procedure to measure albumin, haptoglobin & complement

A

Mephelometry

27
Q

Largest major nonimmunoglobulin in plasma, MW 725 000 Da comparable to that of the major protease inhibitor AAT, although women have higher levels than men in response to estrogen.

A

A2- macroglobulin

28
Q

A2- macroglobulin are high in what condition. More than 3g/dL

A

Nephrotic syndrome

29
Q

AM2 can be identified by

A

Isoelectric focusing

30
Q

Form a complex. No globin. See bubbles due to release of catalase.

A

Haptoglobin

31
Q

Bubbles of oxygen due to

32
Q

Circulation of haptoglobin

A

Reticulo endothelial system

33
Q

Can fresh or stored. C3 cleaved to for C3c them migrate to go to b-globulins

A

Complement

34
Q

Complement deficient protein diseases

A

Autoimmune

35
Q

More appreciated in electrophoresis

36
Q

Most abundant of the coagulation factors and which forms fibrin clot

A

Fibrinogen

37
Q

Produces covalent bonds between lysine and glutamine residues. A crosslinked clot is refractory to dissolution.

A

Factor XIII

38
Q

Functionally deformed fibrinogen. Bleeding problem and more prone to formation of thrombus or clot.

A

Dysfibrinogenemias

39
Q

Essentially no fibrinogen is synthesized results in hemorrhagic disorder

A

Congenital Fibrinogenemia

40
Q

Is a copper binding protein and exhibit oxidase activity. Low at birth and increases in pregnancy, blue color copper then react to yellow chromagens.

A

Ceruloplasmin

41
Q

Greenish if impaired

A

Ceruloplasmin

42
Q

Hepatolenticular degeneration

A

Wilson’s dse

43
Q

Group specific component globulin. Decreased in sever liver disease. D binding protein. In middle of albumin and gamma. Can be found in nephrotic syndrome.

44
Q

Methods for Vit D

A

Rocket, radioimmunoassay

45
Q

Orosomucoid High CHO content. Binds to drugs like lidocaine. Acute phase reactants.

A

A1 acid Glycoprotein

46
Q

Pneumococcal infections, rises strikingly whenever there is tissue necrosis. Capacity to precipitate the C substance.

47
Q

Highly specific for neutralizing chymotrypsin which cleaves peptide bonds at the carboxyl side of tyrosine and phenylalanine residue

48
Q

Response to inflammatory or stressful states that occur with infection or anything that has something to do with

49
Q

Due to malnutrition or gross loss of protein

A

Hypoproteinemia

50
Q

Cut off for nephrotic syndrome albumin

51
Q

Loss of transferrin

A

Iron deficiency anemia

52
Q

Transferrin band forms a narrow clonal

A

Myeloma protein

LAB DIAG (6 decks)

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