M1: Autoimmune(additional)

Question 0

Immunoglobulin abnormal in SLE

Answer 0

IgG

Question 1

Chronic multisystem inflammatory disease. Associated with abnormalities of immune system. Results from interactions among genetic, environmental and immunologic factors. Watch out for renal manifestations. Autoimmune reaction directed against the constituents of cell nucleus, DNA.

Answer 1

SLE

Question 2

Criteria for SLE: person with presence of ________________ with ANA or antidsDNA antibodies or if 4 of dx criteria

Answer 2

Biopsy proven lupus nephritis

Question 3

Cutaneous vascular lesions. Butterfly rash. Oral/nasopharyngeal ulcers. Alopecia.

Answer 3

Dermatologic manifestations

Question 4

Ranging from mild proteinuria to glumerolonephritis.

Answer 4

Lupus Nephritis

Question 5

Primary goal in treatment in SLE

Answer 5

slowing the progression

Question 6

Is a type of antibody directed against the cell’s nuclei. Present in nearly everybody with active lupus. Used as a screening tool. Not enough for a lupus diagnosis. Very sensitive but not specific.

Answer 6

ANA (AntiNuclear Antibody)

Question 7

Are a type of antibody directed against the phospholipids in our body. Present in 60% of people with lupus. A positive test is used to identifywomen with lupus.

Answer 7

Antiphospholipid Antibody

Question 8

Is an antibody directed against SM. A specific protein found in the cell nucleus. Only 30% are positive. Very specific for lupus.

Answer 8

Anti-SM

Question 9

Screening test

Answer 9

High sensitivity

Question 10

Confirmatory test

Answer 10

High specificity

Question 11

Protein directed double stranded DNA. Very specific for lupus. Positive test can be useful in confirming a diagnosis. For monitoring of disease progression.

Answer 11

Anti-dsDNA

Question 12

Are two antibodies that are commonly found together. They are specific against ribonucleic acid proteins. Specific to ribonucleic acid acid. If positive, need to monitor the unborn baby.

Answer 12

Anti Ro(SSA) & Anti La(SSB)

Question 13

Against antigens in the cytoplasm of neutrophil and monocytes.

Answer 13

Antineutrophil Cytoplasmic Antibodies

Question 14

Wegener’s disease (60-90%)

Answer 14

C-ANCA

Question 15

Is a protein in the body that can be the marker of inflammation. Test looks for inflammation.

Answer 15

C-Reactive Protein

Question 16

Are involved in inflammation. The test can look for levels of specific complement.

Answer 16

Complement

Question 17

Measures the speed the RBC moving toward the bottom of a test tube. Marker for inflammation.

Answer 17

ESR

Question 18

A test to assess kidney function and liver function

Answer 18

Panel test

Question 19

Measurement of Glomerular Filtration rate & Proteinuri

Answer 19

Measures kidney effectivity