M1: Pain Flashcards
Unpleasant sensory and emotional experience associated with actual or potential tissue damage. It is both a sensation and emotion as it is accompanied by anxiety and the urge to escape or terminate the feeling.
Pain
The ability to experience pain is essential for
Protection from Injury
Associated with risk of tissue damage due to undiscovered injury.
Insensitivity to Pain
Should be recognized as a human right
Relief from Pain
Should be considered a disease in its own right
Chronic Pain
Should have the full status of a specialty
Pain medicine
Transmit pain impulses
A-delta & C fibers
Transmit light touch
A-beta
In the presence of inflammatory mediators, primary afferents. Have lower thresholds for pain, increased frequency of firing and become sensitive to certain stimuli which usually do not cause pain.
Sentisization
Contribute to the process of Sensitization
Inflammatory mediators
Examples of Inflammatory mediators
Prostaglandin, Leukotrienes, Bradykinin & Nerve GF “PaLaBaN”
Have a neuroeffector function and not just passive messengers of threats to tissues.
Primary Afferent Nociceptors
When activated, some nociceptors may release polypeptide mediators such as Substance P causing vasodilation, degranulation of mast cells, attracts leukocytes and increases production of inflammatory mediators.
Nociceptor-Induced Inflammation
Subserves the sensory aspect of pain
Thalamus
Subserves the emotional aspect of pain
Higher Cortical Levels
Five categories of Pain
Duration & Severity, Anatomical location, Body system involved, Cause and Temporal characteristics “DAB CT”
Pain that is of recent onset and resolves quickly
Acute
Pain that lasts a long time. Pain that extends beyond the expected period do healing.
Chronic
More than 6months
Chronic
Within 1-6 months
Subacute