M03 Flashcards
M03
Define MALT & give examples
- Unencapsulated tissue of the digestive, respiratory, urinary & reproductive tracts
Examples: tonsils, Peyer’s patches in the ileum
Explain the functions of lymph nodes
- Filter lymph to remove pathogens and foreign particles.
- Produce lymphocytes
Know which lymph nodes receive lymph from which regions of the body
Where is the thymus located?
in the mediastinum, posterior to the sternum & between the lungs
Which cells mature in the thymus?
T lymphocytes (T cells)
What are the hormones produced in the thymus?
Thymosin & Thymopoietin
What happens to the thymus as people age?
it gets smaller as you age
Where is the spleen located?
upper left quadrant
Describe the two tissue types in the spleen
- white pulp (lymphocytes)
- red pulp (RBCs & macrophages)
Explain the functions of the spleen
- filters blood
- removes old or damaged RBCs
- stores platelets
- initiates immune responses to blood-borne antigens
Define immunity
the ability of an organism to resist a specific infection or toxin by the action of specific antibodies
Define pathogen
microorganism that causes disease
Compare and contrast innate defenses and adaptive defenses. It could be beneficial to make a table and compare general characteristics (like if they are non-specific or specific), what cells are involved in each, and examples of each (for example, an example of an innate defense is the complement system. An example of an adaptive defense is antibody). Note: there is a lot to know about innate and adaptive defenses. All of the remaining questions on this document tie into innate and adaptive defenses
Give examples of physical/mechanical barriers
Name 4 signs/symptoms of inflammation and explain what causes them
Give examples of chemical barriers and explain the functions of each of the chemical barriers
Explain the function of Natural Killer cells
Define phagocytosis. Name the two most active phagocytic cells
Define chemotaxis
Which cells become macrophages?
Why is fever important?
inhibits microbial growth which then causes the liver & spleen to take up iron, making it unavailable for bacteria & fungi to use their normal metabolism
Define antigen and antibody and make sure that you understand the difference between the two. These terms are often confused. Know that antibodies are also called immunoglobulins
Define the cellular (cell-mediated) immune response
Define the humoral immune response
Know the two main types of lymphocytes and where each matures. Explain functions of lymphoctyes
T cells:
- mature in the thymus
B cells:
- mature in red bone marrow
Explain how T cells are activated
requires antigenic fragments to be attached to antigen-presenting cell (APC, accessory cell)
Define major histocompatibility complex
Name the three types of T cells and explain their functions
Helper T Cells:
- activate other cells
- stimulate B cells to produce antibodies
Explain how B cells are activated
when an antigen fits the shape of their receptors & binds to them ……further activation requires cytokines from T cells
Explain the functions of memory B cells and plasma cells
Memory B Cells:
provide future immune protection
Plasma Cells:
produce & secrete antibodies/immunoglobulins