M&R Flashcards
When do you use the concentration response curve?
When looking at a response in tissues or cells
What is a logarhythm?
Exponent by which a value (fixed) has to be raised to give a particular number
When do you use a dose response curve?
When looking at a response in a whole animal
What is the EC50?
The effective concentration that gives 50% of the maximum response
What is the EC50 a measure of?
Potency
What is the IC50?
The inhibitor concentration giving 50% maximum inhibition
What are carbohydrates important for in terms of the cell an membranes?
Cellular and immune recognition
How do carrier molecules move?
Ping pong
When is the NCX used?
Action potential in heart
Reverses in ischaemia so leads to toxicity
How do you work out unmyelinated axons velocity?
It’s proportional to square root of diameter
How do you work out myelinated axons velocity?
It’s proportional to diameter
What are dihydropyramidines used for?
Block L type calcium channels
What G protein does perrsutis toxin work on?
Gi
It stops GDP -> GTP
What G protein does cholera toxin work on?
Gs
Stops GTP -> GDP
What action so micro opioids do?
Reduce calcium
Interact with Gi
What is potency?
Ability to elicit half of the maximum response
Where does first order kinetics take place?
Kidney
Where does 0 order kinetics take place?
Liver by oxidation of cytochrome p450 system
Where are the ion channels in myelinated axons?
Channels are concentrated in the node
Where are non-myelinated ion channels?
Spread out across the axon
Name some disorders of PNS
Charot Marie tooth
Landry guillian barre syndrome
Name 2 disorders of CNS and explain the difference
Multiple sclerosis
Devics disease
Devics disease is in optic nerve and spine only
What is patch clamping?
Enables currents through individual ion channels
Tyrosine to dopa enzyme?
Tyrosine hydroxylase
