Lysosomes

Question 1

Pompe’s Disease

Answer 1

• Alpha-glycosidase
• neuromuscular disease of infants, children and adults (most often muscles of breathing, heart and mobility affected); build-up of glycogen in lysosomes expands organelle, excess glycogen and enzymes leak out damaging muscle; missing lysosomal enzyme is alpha-glycosidase

Question 2

Tay-Sach’s Disease

Answer 2

-Hexosaminidase A

1 in 27 are carriers and 1 in 250 get the disease (Jews of central and eastern European descent, French Canadian communities of Quebec, old order Amish in PA, Cajuns in LA) – babies born without Hexosaminidase A which allow fatty proteins to build up in the brain (affects sight, hearing, movement and mental development)

Question 3

Gout

Answer 3

hperuricemia in blood; depositing in joints (arthritis) and kidneys (stones); pierced lysosomal membranes release enzymes.