LYSOSOMAL STORAGE DISEASES

Question 1

flawed degradation of phagocytized material and buildup of undigested substrates within lysosomes

Answer 1

LYSOSOMAL STORAGE DISEASES

Question 2

-The macrophages are particularly prone to accumulate undegraded lipid products, which subsequently leads to an expansion of the reticuloendothelial tissue

Answer 2

LIPID STORAGE DISEASES/ SPHINGOLIPIDOSES

Question 3

-Are qualitative disorders involving monocytes and macrophages

Answer 3

LIPID STORAGE DISEASES/ SPHINGOLIPIDOSES

Question 4

-most common of the lysosomal lipid storage diseases ; at least 1 in 17 Ashkenazi Jews are carriers

Answer 4

GAUCHER’S DISEASE

Question 5

-It is an autosomal recessive disorder caused by a defect or deficiency in the catabolic enzyme beta-glucocerebrosidase

Answer 5

GAUCHER’S DISEASE

Question 6

can be found in bone marrow of some patients with thalassemia, chronic myeloid leukemia, acute lymphoblastic leukemia, non-Hodgkin lymphoma, and plasma cell neoplasms

Answer 6

Pseudo-Gaucher cells