LEUKOCYTE MORPHOLOGICAL ABNORMALITIES (GNA) Flashcards
GRANULOCYTES NUCLEAR ABNORMALITIES
have more than five lobes and are usually larger than normal neutrophils
HYPERSEGMENTATION/HYPERSEGMENTED NEUTROPHILS
- peanut shaped
HYPOSEGMENTED NEUTROPHILS
(“pince-nez”, dumbell peanut)
HYPOSEGMENTED NEUTROPHILS
(Homozygous[more dangerous) Pelger-Huet)
HYPOSEGMENTED NEUTROPHILS
contain 3-5 lobes that are separated by filaments
Normal neutrophils
neutrophil that has ingested the antibody- coated nucleus of another neutrophil
LE CELL
engulf the homogenous, globular nuclear mass of destroyed cell
LE CELL
tart cell (monocyte with an ingested lymphocyte)
LE CELL
Represents the 2nd X chromosome in females
BARR BODY(SEX CHROMATIN)
seen 2-3% of neutrophils
BARR BODY(SEX CHROMATIN)
Characteristic “DRUMSTICK” appearance of neutrophils
BARR BODY(SEX CHROMATIN)
Megaloblastic anemia Undritz anomaly→ Hereditary neutrophil hypersegmentation Myelodysplasia
HYPERSEGMENTATION/HYPERSEGMENTED NEUTROPHILS
Systemic Lupus Erythematosus
LE CELLS
Pseudo or Acquired Pelger-Huet anomaly
Hyposegmented Neutrophils