Lynch Syndrome

Question 1

What is the prevalence of Lynch syndrome?

What percentage of CRCs does it account for?

Answer 1

1/440

1-3%

Question 2

What is effected in Lynch syndrome?

Answer 2

Mismatch repair where MLH1, MSH 2, MSH 6 and PMS 2 are effected.

Question 3

What causes lynch syndrome?

Answer 3

Disease causing (pathogenic or likely pathogenic) variants?

Question 4

What is the negative of lynch syndrome?

Answer 4

Puts you at higher risk of developing certain types of cancers including colorectal, endometrial and ovarian.

Other cancers include, small bowel, gastric, brain, ureter, renal pelvis, hepatobillary, pancreatic and sebaceous skin tumours.

Question 5

What are examples of carrier management?

Answer 5

Screening
Risk reducing surgeries
Research
Cancer management 
Family matters 
Chemoprevention

Question 6

What are examples in screening for lynch syndrome?

Answer 6

Symptom awareness
Gastric
Colorectal

Question 7

Chemoprevention example for lynch syndrome

Answer 7

Low dose asprin

Question 8

Risk reducing surgery example?

Answer 8

Hysterectomy +/- BSO

Question 9

Lynch syndrome - testing eligibilty?

Answer 9