Calcium and Phosphate Metabolism Flashcards

1
Q

What is a genetic cause of osteomalacia?

A

Mutations leading to errors in vit D metabolism (rare)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is a genetic cause of osteomalacia?

A

Mutations leading to errors in vit D metabolism (rare)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is a genetic cause of secondary hyperparathyroidism?

A

• Alpha hydroxylase mutation and/or vit D receptor mutation = low calcium and active calcitriol will be low = high PTH = secondary hyperparathyroidism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is FGF-23?

What are disorders linked to FGF-23?

A

FGF-23: a hormone secreted by osteocytes
• Phosphate balance: increases renal excretion
• Disorders:
• Oncogenic osteomalacia (tumour secreting FGF-23)
• X-linked hypophophataemic rickets
• Autosomal dominant hypopho-phataemic rickets (gain of function mutation)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly