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Hematology 4 > Lymphoproliferative Neoplasia > Flashcards

Lymphoproliferative Neoplasia Flashcards

1
Q

What are the subcategories of Lymphoproliferative neoplasm?

A
  • ALL
  • CLL
  • PLL (Prolymphocytic leukemia)
  • HCL (Hairy cell leukemia)
  • Hodgkin’s/Non-Hodgkin’s
  • MM / Waldenstrom’s
  • PCL (Plasma cell leukemia)
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2
Q

What kind of testing can be used to identify ALL?

A
  • Immunophenotyping
  • Cytochemical
  • Flowcytometry
  • Other testing: (lumber puncture, CT, Ultrasounds)
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3
Q

What is the treatment for ALL?

A
  • Chemotherapy
  • Bone marrow transplant
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4
Q

What is the L1 subcategory of ALL and who is it generally seen in?

A

Lymphoblastic leukaemia with homogenous structure, children

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5
Q

What is the L2 subcategory of ALL and who is it generally seen in?

A

Lymphoblastic leukaemia with varied structures, older children & adults

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6
Q

What is the L3 subcategory of ALL?

A

Burkitt’s leukeamia

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7
Q

Which is the most common Lymphoproliferative leukemia which has no identified cause and mostly affects ELDERLY patients.

A

CLL

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8
Q

In CLL what is the common morphology of lymphocytes?

A

TURTLE SHELL (abnormal/atypical lymphs)

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9
Q

When you have CLL and AIHA and ITP all combined what syndrome is this called?

A

Evans Syndrome

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10
Q

What are symptoms of CLL?

A
  • Enlarged lymph nodes
  • splenomegaly/ hepato
  • night sweats
  • fatigue
  • weight loss
  • fever
  • shingles, cold sores
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11
Q

What are the stages of CLL according the RAI classifications?

A

0 - Lymphocytosis only
1- Lyphocytosis + Lymphadenopathy
2 - Lymphocytosis + enlarged spleen/liver
3- lymphocytosis + anemia
4- Lymphocytosis + platelets

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12
Q

What is a subcategory of chronic leukemia.

A

Hairy cell leukemia

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13
Q

What is lymphoma?

A

Solid mass tumor of the lymphatic system involves lymphocyte production and antiapoptotic mutation

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14
Q

what are the two main categories of lymphoma?

A
  • Hodgkin’s lymphoma (10%)
  • Non-hodgkin’s (90%)
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15
Q

What are some predisposed conditions which could lead to lymphoma?

A
  • Depressed immune system
  • HIV , EBV, H.pylori infections
  • family history
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16
Q

What are symptoms of lymphoma?

A
  • Swelling of lymph nodes
    (Neck, armpit, groin)
  • Fever, night sweats
  • Difficulty breathing
  • Weight loss
  • Headaches
17
Q

How is lymphoma diagnosed?

A
  • Physical exam
  • Diagnostic imaging
  • Biopsy / bone marrow
  • Immunophenotyping/ flow/ FISH
18
Q

What is the name of the lymphocytes which can be seen in hodgkin’s lymphoma? Where are they located?

A

Reid Sternberg cells
- Lymph node / BM

19
Q

What are the 4 stages of hodgkin’s lymphoma?

A

1- localized w/i a lymph node
2- seen in 2+ lymph nodes
3- spread to lymph nodes above and below diaphragm
4- spread to tissue outside of the lymphatic system

20
Q

In Hodgkin’s lymphoma what might be seen in the PBF of a leukemic phase?

A

Clefted lymphocytes “Butt crack cells”

21
Q

What is the treatment for hodgkin’s lymphoma?

A
  • Radiation
  • Chemotherapy
  • Autologous bone marrow transplant
  • CAR T-cell therapy
22
Q

What are the 4 main subcategories of non hodgkins lymphoma?

A
  • Precursor B cell
  • Peripheral B-cell
  • Precursor T cell
  • Peripheral T cell
23
Q

What is the name of the lymphoma that forms in the outer edge of the lymphnode?

A

Mantle cell lymphoma

24
Q

Which is the most common NH Lymphoma?

A

Follicular Lymphoma

25
Q

What may be seen in follicular lymphoma?

A

Clefted lymphs

26
Q

Which NH lymphoma is characterized by brain shaped folded nucleus and erythroderma?

A

Sezary Cell lymphoma

27
Q

What is multiple myeloma?

A

Uncontrolled proliferation of Plasma cells in BM

28
Q

Which condition is characterized by the presence of bence jones proteins in the urine and increase serum calcium levels?

A

Multiple Myeloma

29
Q

What might be seen in the PBF of a patient with Multiple myeloma?

A

Plasma cells
Rouleaux - Background staining

30
Q

Which condition is characterized by the presence of Bense Jones proteins in the urine and cryoglobulin on a PBF?

A

Waldenstrom’s macroglobulinemia

31
Q

Which leukemia is characterized by a rare and agressive proliferation of plasma cells with unknown cause.

A

Plasma cell leukemia

Hematology 4 (4 decks)

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