LYMPHOPROLIFERATIVE DISORDERS OBJECTIVES Flashcards
CANCER OF WBCS/BLOOD/BONE MARROW
Leukemia
Increased total WBC count
Leukocytosis
Increased neutrophil count
Neutrophilia
Increased lymphocyte count
Lymphocytosis
Decreased total leukocyte count
Leukopenia
Decreased neutrophil count
Neutropenia
Decreased lymphocyte count
Lymphoctyopenia
All blood lineages decreased
Everything wiped out
Pancytopenia
Describe Leukomoid reaction
What does it look like?
Leukemia like infection involving marked increase in neutrophilia…
Response to infection and is def not leukemia…
Most closely resembles Chronic Myelocytic Leukemia (CML)
Differentiate acute lymphocytic leukemia (ALL), acute myelocytic
leukemia (AML), chronic lymphocytic leukemia (CLL), and chronic
myelocytic leukemia (AML) in terms of which is most common in
adults, which is most common in children, sex/age of the afflicted,
laboratory diagnosis, and prognosis
Most common in Adults: CLL (>50 y/o)
Most common in children: ALL (3-7 y/o)
Identify the bone marrow cell that is characteristic of Hodgkin’s
lymphoma, and identify the key characteristic(s) of each stage of
lymphoma progression
Hodgkins characterized by giant Reed-Sternberg cells
Stage 1: Cancer located in a single lymph node
Stage 2: 2 or more lymph node groups on one side of the diaphragm
Stage 3: Cancer has spread to both sides of the diaphragm, or involves the spleen
Stage 4: Cancer involves liver, bone marrow, lung and brain…
-highly metastasized
Acute Lymphocyte Leukemia (ALL)
Most common in children ages 3-7 y/o
>20 % lymphoblastic in blood and marrow
-WBC’s very high or very low
-Tdt: lymphoblastic express Terminal deoxynucleotidyl transferase
>70% overall; 95% for children
Acute Myeloid Leukemia (AML)
-Primarily adult median age 55 y/o
>20% blasts in blood or bone marrow
-WBC’s very high or low
Auer rods= crystallized granules in myeloblasts
-Death if untreated; 25% 5 yr survival overall
Chronic Myeloid Leukemia (CML)
- Philadelphia chromosome
- Primarily Adult median age 50 y/o
- Elevated WBC 950-300K)
- full spectrum of immature- mature neutrophils - 60% 5 yr survival
- Gleevec trials demonstrate >80% remission
Chronic Lymphocytic Leukemia (CLL)
Most common Adult Leukemia -Adults: >50 y/o Elevated WBC's (>20K) -lymphocytosis (75-98%) -may present as lymphoma MEd survival ~10 years (stage 1 and 2) <2 years (stages 3 and 4)