Lymphopoiesis

Question 1

All blood cells are derived from?

Answer 1

Pluripotential stem cells

Question 2

The lymphoid committed stem cell divides into?

Answer 2

Pre-B and pre-T cells

Question 3

The LCSC is usually identifiable by a cluster of differentiation antigen named?

Answer 3

CD10+

Question 4

Receptors often found on the membrane of cells and used to identify these cells are called?

Answer 4

Cluster of differentiation antigens

Question 5

What does CALLA stand for?

Answer 5

Common Acute Lymphoblqstic leukemia Antigen

Question 6

Where is the Pre B-cell found?

Answer 6

At the center of HIM

Question 7

How is the Pre B-cell indentified?

Answer 7

By the demonstration of Ig gene arrangement by molecular technique

Question 8

All cells contain the same no of chromosomes and different No of genes as inherited at fertilization. T/F?

Answer 8

False. They are both the same

Question 9

The genes present in all tissues of the body inherited at fertilization is called?

Answer 9

GERM LINE INHERITANCE

Question 10

Germ line inheritance is arranged in two cell types in the human body namely?

Answer 10

B lymphocytes
T lymphocytes

Question 11

Gene rearrangement occurs in B-lymphocyte why?

Answer 11

To give the body capacity to form antibody to any type of antigen found in nature

Question 12

To produce an antibody against a foreign gene there must be —— circulating in the blood

Answer 12

B-cell which has Ig expressed on it’s membrane

Question 13

Every B-cell in the body is different from the other. T/F?…. Give reason

Answer 13

True! Because they all express different surface membrane Igs

Question 14

Antibodies can still be formed without pre-existing genes. T/F

Answer 14

False

Question 15

The ability of the body to form different B-Cells that will express different surface membrane of Ig, lies where?

Answer 15

In Gene re-arrangement phenomenon

Question 16

If a B-cell is going to be formed it has ———

Answer 16

Germ line Ig gene

Question 17

B-cell re-arranges the germ line Ig gene for it to be able to perform a particular type of —— to a given —— in nature

Answer 17

Antibody, Antigene

Question 18

Each cell rearranges the GEM line Ig gene for it to produce a unique —— to a given —— in nature!!

Answer 18

Antibody, antigene

Question 19

Some of the B-cells have the germ line Ig gene. T/F

Answer 19

False

Question 20

To form an Ig molecule, you’ll form both —— and —— of Ig

Answer 20

Heavy and light chain

Question 21

The further development of B-cell after it enters circulation is by?

Answer 21

ANTIGENIC STIMULATION

Question 22

The further development of B-cell will continue in the peripheral circulation. T/F

Answer 22

False! It continues in the lymph node

Question 23

The antigenically stimulated B-cells hones to what?

Answer 23

Lymph node follicles

Question 24

When B-cells become activated they also express what receptor?

Answer 24

CD 23

Question 25

Area of paracortex that merged with lymph node follicle of called?

Answer 25

Marginal Zone

Question 26

Mantle zone is—-

Answer 26

Area of follicle that is inner to the marginal zone

Question 27

What area of lymph node does the antigenically stimulated Virgin B-cells go to?

Answer 27

Follicular Center!