Lymphoma Flashcards
What are the two types of lymphoma
Hodgkin and Non Hodgkin
What is the main presentation of either type of lymphoma
B sings
Low grade fever, night sweats, weight loss
What is the spread of Hodgkins lympoma
Localized, single group of nodes with contiguous spread overall prognosis is better than non hodgkin
What is the strongest predictor of hodgkin prognosis
STAGE
What are the primary characteristics of hodgkins lympoma
Reed Sternberg Cells
are CD15 and CD30 + Bcells
What is the Distribution in age groups among Hodgkin lymphoma
Bimodal; young adult and >55
More common in men (except nodular sclerosing type)
What condition is Hodgkin lympoma associated with
EBV
What is the spread of Non Hodgkins lympoma
Multiple lymph nodes involved; extranodal involvement is common with noncontiguous spread
What are the primary characteristics of Non hodgkins lympoma
most invovle b cells
few are of t cell lineage
What is the Distribution in age groups among Non Hodgkin lymphoma
Can occur in children or adults
What condition is Non Hodgkin lympoma associated with
May be associated with HIV and autoimmune
What is the most common type of hodgkin lymphoma
Nodular sclerosing type
What Hodgkin lympoma has the best prognosis
lymphocyte rick
Which hodgkin lympoma is associated with eosinophilia
Mixed cellularity
seen in immunocompromised pts
Which hodgkin lymphoma is only seen in immunocompromised pts
lymphocyte depleted
What are the genetic alterations associated with:
Burkitt lymphoma
T( 8 ; 14 )
tranlslocation of c-myc (8) and Heavy chain Ig (14)
What are the genetic alterations associated with:
Diffuse large b cell lymphoma
alterations in BCL2, BCL6
What are the genetic alterations associated with:
Follicular lymphoma
T( 14 ; 18 )
translocation of Heavy chain Ig (14) and BCL2 (18)
What are the genetic alterations associated with:
Mantle cell lymphoma
T( 11 ; 14 )
Translocation of cyclin D1 (11) and Heavy chain Ig (14)
CD 5+
What are the genetic alterations associated with:
Marginal zone lymphoma
T( 11 ; 18 )
What are the genetic alterations associated with:
Primary central nervous system lymphoma
most commonly associated with HIV/AIDS
involves EBV infection
What are the genetic alterations associated with:
Adult T Cell lymphoma
Caused by HTLV; associated with IV drug abuse
common in Japan West Africa and caribean
What are the genetic alterations associated with:
Mycosis fungoides/sezary syndrome
Cutaneous T cell Lymphoma (may progress to Sezary syndrome T cell leukemia)
What Non hodgkin lymphoma presents as stary sky of sheets of lymphocytes with tingible body macrophages
Burkitt lymphoma
What is the most common type of Non hodgkin lymphoma in adults
Diffuse large B cell lymphoma
What are the characteristics of follicular lymphoma
Indolent course presenting with painless waxing and waning lymphadenopathy
What are the characteristics of mantle cell lymphoma
Very agressive typically see at a late stage
What Non hodgkin lymphoma is associated with chronic inflamation like sjogren or chronic gastritis
Marginal zone lymphoma
How does primary central nervous system lymphoma present
Aids defining illness variable with confusion memory loss or seizures
lesions may be ring enchancing and needs to be distinguished from toxo via csf analysis
What characterizes the cells of mycosis fungoides
Atypical CD4+ cells with cerebriform nuclei and intraepidermal neoplastic cell aggregates
Pautrier microabscesses
What is the endemic form and sporadic form of burkitt lymphoma
Endemic: jaw lesion in africa
Sporadic: pelvis or abdomen
