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-Heme/Onc > Lymphoma > Flashcards

Lymphoma Flashcards

1
Q

What are the two types of lymphoma

A

Hodgkin and Non Hodgkin

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2
Q

What is the main presentation of either type of lymphoma

A

B sings

Low grade fever, night sweats, weight loss

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3
Q

What is the spread of Hodgkins lympoma

A

Localized, single group of nodes with contiguous spread overall prognosis is better than non hodgkin

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4
Q

What is the strongest predictor of hodgkin prognosis

A

STAGE

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5
Q

What are the primary characteristics of hodgkins lympoma

A

Reed Sternberg Cells

are CD15 and CD30 + Bcells

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6
Q

What is the Distribution in age groups among Hodgkin lymphoma

A

Bimodal; young adult and >55

More common in men (except nodular sclerosing type)

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7
Q

What condition is Hodgkin lympoma associated with

A

EBV

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8
Q

What is the spread of Non Hodgkins lympoma

A

Multiple lymph nodes involved; extranodal involvement is common with noncontiguous spread

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9
Q

What are the primary characteristics of Non hodgkins lympoma

A

most invovle b cells

few are of t cell lineage

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10
Q

What is the Distribution in age groups among Non Hodgkin lymphoma

A

Can occur in children or adults

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11
Q

What condition is Non Hodgkin lympoma associated with

A

May be associated with HIV and autoimmune

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12
Q

What is the most common type of hodgkin lymphoma

A

Nodular sclerosing type

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13
Q

What Hodgkin lympoma has the best prognosis

A

lymphocyte rick

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14
Q

Which hodgkin lympoma is associated with eosinophilia

A

Mixed cellularity

seen in immunocompromised pts

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15
Q

Which hodgkin lymphoma is only seen in immunocompromised pts

A

lymphocyte depleted

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16
Q

What are the genetic alterations associated with:

Burkitt lymphoma

A

T( 8 ; 14 )

tranlslocation of c-myc (8) and Heavy chain Ig (14)

17
Q

What are the genetic alterations associated with:

Diffuse large b cell lymphoma

A

alterations in BCL2, BCL6

18
Q

What are the genetic alterations associated with:

Follicular lymphoma

A

T( 14 ; 18 )

translocation of Heavy chain Ig (14) and BCL2 (18)

19
Q

What are the genetic alterations associated with:

Mantle cell lymphoma

A

T( 11 ; 14 )
Translocation of cyclin D1 (11) and Heavy chain Ig (14)
CD 5+

20
Q

What are the genetic alterations associated with:

Marginal zone lymphoma

A

T( 11 ; 18 )

21
Q

What are the genetic alterations associated with:

Primary central nervous system lymphoma

A

most commonly associated with HIV/AIDS

involves EBV infection

22
Q

What are the genetic alterations associated with:

Adult T Cell lymphoma

A

Caused by HTLV; associated with IV drug abuse

common in Japan West Africa and caribean

23
Q

What are the genetic alterations associated with:

Mycosis fungoides/sezary syndrome

A

Cutaneous T cell Lymphoma (may progress to Sezary syndrome T cell leukemia)

24
Q

What Non hodgkin lymphoma presents as stary sky of sheets of lymphocytes with tingible body macrophages

A

Burkitt lymphoma

25
Q

What is the most common type of Non hodgkin lymphoma in adults

A

Diffuse large B cell lymphoma

26
Q

What are the characteristics of follicular lymphoma

A

Indolent course presenting with painless waxing and waning lymphadenopathy

27
Q

What are the characteristics of mantle cell lymphoma

A

Very agressive typically see at a late stage

28
Q

What Non hodgkin lymphoma is associated with chronic inflamation like sjogren or chronic gastritis

A

Marginal zone lymphoma

29
Q

How does primary central nervous system lymphoma present

A

Aids defining illness variable with confusion memory loss or seizures
lesions may be ring enchancing and needs to be distinguished from toxo via csf analysis

30
Q

What characterizes the cells of mycosis fungoides

A

Atypical CD4+ cells with cerebriform nuclei and intraepidermal neoplastic cell aggregates
Pautrier microabscesses

31
Q

What is the endemic form and sporadic form of burkitt lymphoma

A

Endemic: jaw lesion in africa
Sporadic: pelvis or abdomen

-Heme/Onc (6 decks)

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