Lymphoma

Question 1

What is the most common category of lymphoma?

Answer 1

Non-Hodgkins (80%)

Question 2

At what age do non-hodgkins lymphomas NOT present after?

Answer 2

40

Question 3

75% of lymphoma pts present with?

Answer 3

Lymphadenopathy

Question 4

In a pt with lymphoma… bleeding, anaemia and recurrent infections suggest what?

Answer 4

Infiltration into the bone marrow leading to BM failure

Question 5

Do NHL mostly derive from T or B cell lines?

Answer 5

B cell lines

Question 6

What is the system used to stage lymphomas?

Answer 6

Ann Arbor system

Question 7

What bloods would you run for NHL?

Answer 7

FBC, U+E, LFT, LDH (raised LDH indicates worse prognosis = increased cell turnover)

Question 8

How curable are low grade NHL’s?

Answer 8

Almost incurable

Question 9

How curable are high grade NHL’s?

Answer 9

Curable

Question 10

What is jaw lymphadenopathy in children characteristic of?

Answer 10

Burkitt’s lymphoma

Question 11

What feature must a lymphoma have to be a hodgkin lymphoma?

Answer 11

Reed-Sternberg Cells

Question 12

What is the sex ratio of Hodgin’s?

Answer 12

M2:1F

Question 13

Hodgkin’s has a bimodal age distribution, what ages?

Answer 13

20’s and over 60

Question 14

What infection is hodgkin’s associated with?

Answer 14

EBV

Question 15

Mediastinal lymph nodes in hodgkin’s can obstruct two structures…?

Answer 15

Bronchus

SVC

Question 16

Investigations for Hodgkin’s?

Answer 16

Lymph node biopsy

FBC, blood film, ESR, LFT, LDH, urate, Ca

Question 17

A Hodgkin’s pt has two nodal areas affected in the thorax. What ann arbor staging are they?

Answer 17

2

Question 18

A Hodgkin’s pt has two nodal areas affected, one in the thorax, another in the abdomen. What ann arbor staging are they?

Answer 18

3

Question 19

5 year prognosis of an Ann Arbor stage 4 HL?

Answer 19

<40%

Question 20

5 year prognosis of an Ann Arbor stage 1 HL?

Answer 20

95%