Lymphoma Flashcards
What is the 7th most common cause of cancer death
Lymphoma
Lymphoma has a predominance for M/F?
Males
Although females are more common for follicular lymphoma
At what age can lymphoma occur
all ages
avg age is 42
3% of what pts will develop lymphoma
AIDS pts
Name two probable contributors of why there is an increase in incidence of AIDS pt developing lymphoma
phenoxyherbicide use and aging of pop.
80% of lymphomas are from what origin
B-cell
What pathogen is associated with Hodgkin’s
EBV
What is the gold standard for lymphoma diagnosis
excisional biopsy
needle biopsy can be used to determine if a mass is lymphomatous BUT to see the histo of it excisional is best
What 3 things do clinicians and pathologist have to communicate clearly about
- certainty of diagnosis
- quality of material available for interpretation
- clinical course going to be taken
What is the most characteristic feature of B-cell lymphoma
painless LN enlargement
can have a “rubbry” feel
What is the predominant classification of lymphoma
nodal presentation
what is nodal presentation
invovlemnt of LN and other lymphoid structures like the liver and spleen
what is the extra-nodal presentation
rarer and important to recognize bc treatment may be site specific
the Ann Arbor staging stages what?
Hodgkins Disease
Ann Arbor staging is …
limited and extensive
Why is Ann Arbor staging used
to differentiate btwn available treatment options
what often has microscopic disease at distant sites demonstrated by subsequent relapse
clinically localized low grade lymphoma
what has a greater probability of being pathologically localized
higher grade clinically localized lymphoma
it can also turn widespread but if diagnosed quickly and treated it can be cured
what is the main reason staging procedures are chosen
to guide therapy selection
what was the main criteria of the NCI working formulation classifcation
morphologic
which classification system utilized immunophenotypic and genetic data
REAL and WHO
what is the translocation for Follicular lymphoma
t(14,18)
what is the translocation for Burkitt’s lymphoma
t(8,14)
what is the translocation for mantle cell lymphoma
t(11,14)
what is the survival rate for mantle cell lymphoma
3-5 years
what are the diagnostic markers for mantle cell
sIgM+ IgD+
CD19,20,79a+
CD5+ 10+/- 11c- 23- 43+.
what is the general main marker for indolent lymphoma
KI67
Treatment he bolded for mantle cell
Ibrutinib
What type of lymphoma is follicular center
generally indolent with widespread disease
What are the markers for follicular center
sIgM+/- IgD+ /-
CD19,20,79a+
CD5- 10+ 11c- 23-/+ 43-.
Marginal zone B-cell lymphoma: extra-nodal ?
Low-grade B-cell Lymphoma of MALT type, ( ± monocytoid B cells)
Marginal zone B-cell lymphoma: nodal ?
( ± monocytoid B cells)
What disease are Marginal zone B-cell lymphoma associated with?
autoimmune disease related (Sjogren’s, Hashimoto’s),
helicobacter related gastric MALT lymphoma.
what are the markers for mantle cell
sIgM+/- IgD+ /-
CD19,20,22,79a+
CD5- 10- 11c+/- 23- 43-/+
What genetic defect is associated with mantle cell
trisomy 3
what kind of lymphoma is mantel cell
indolent and localized
cured with local treatment
can use Ab to treat h. pylori in gastric MALT lymphoma
what is used for advanced NHL
CHOP with 3 intensive chemo
what is used in relapses of chemo-sensitive NHL
Autologous Bone marrow transplant (Auto-BMT)
What is the only approved treatment for low grade lymphoma
Rituxan -monoclonal Antibody therapy
targets CD20
what were rituxan’s side effects
fever, chills
occurs mainly on first infusion
