7 Hem Onc Viruses Keller

Question 1

Dengue virus. This virus is typically found in ___. Dengue virus is a flavivirus and is transmitted via ___. A classic symptom includes ___ from the nose and gums.

Answer 1

The virus is typically found in SOUTH AMERICA. Dengue virus is a flavivirus and is transmitted via MOSQUITOES. A classic symptom includes BLEEDING from the nose and gums.

Question 2

Dengue virus. Immunopathogenesis is caused by ___ dependent enhancement. This typically occurs after a prior infection with a dengue serotype. Neutralizing ___ produced from a previous exposure to dengue virus, will increase viral entry into ___ increasing viral infection throughout the body.

Answer 2

Immunopathognesis is caused by ANTIBODY dependent enhancement. This typically occurs after a prior infection with a dengue serotype. Neutralizing ANTIBODIES produced from a previous infection will increase viral entry into MONOCYTES increasing viral infection throughout the body.

Question 3

Lassa Fever Virus is transmitted by ___ excrement.

Answer 3

Lass Fever Virus is transmitted by MOUSE excrement.

Question 4

Rift Valley Fever is transmitted by ___.

Answer 4

Rift Valley Fever is transmitted by MOSQUITOS.

Question 5

Crimean-Congo Hemorrhagic Fever are transmitted by ___.

Answer 5

Crimean-Congo Hemorrhagic Fever are transmitted by TICKS.

Question 6

Ebola and Marburg transmission remains unknown but is suspected to be transmitted from ___.

Answer 6

Ebloa and Marburg transmission remains unknown but is suspected to be transmitted from MONKEYS.

Question 7

Esptein-Barr Virus. This virus is an enveloped, double-stranded ___ virus and is a member of the ___ family.

Answer 7

This virus is an enveloped, double-starnded DNA virus and is a member of the HERPRESVIRIDAE family.

Question 8

Esptein-Barr Virus. Bind to the ___ receptor on B cells and some epithelial cells located in the oropharynx and nasopharynx regions. Infected cells will ___ and enters through the ___.

Answer 8

Bind to CD21 receptors on B cells and some epithelial cells located in the oropharynx and nasopharynx regions. Infected cells will PROLIFERATE and enter through the BLOOD STREAM.

Question 9

Esptein-Barr Virus. ___ cells will proliferate and become activated in order to limit infected B cell proliferation.

Answer 9

CD8+T cells will proliferate and become activated in order to limit infected B cell proliferation.

Question 10

Esptein-Barr Virus. Remains latent in ___ B cells and may become reactivated if these cells are stimulated.

Answer 10

Remains latent in MEMORY B cells and may become reactivated if these cells are stimulated.

Question 11

Esptein-Barr Virus. In immunocompromised patients, EBV may be associated with ___ development.

Answer 11

In immunocompromised patients, EBV may be associated with CANCER development.

Question 12

Esptein-Barr Virus. Transmitted through ___ and causes infectious ___ in teenagers and adults and a variety of ___ disorders, including B cell lymphomas.

Answer 12

Transmitted through SALIVA and causes infectious MONONUCLEOSIS in teenagers and adults and a variety of LYMPHOPROLIFERATIVE disorders, including B cell lymphomas.

Question 13

Esptein-Barr Virus. Diagnosis is confirmed by the presence of ___ lymphocytes and a ___ heterophile antibody test.

Answer 13

Esptein-Barr Virus. Diagnosis is confirmed by presence of ATYPICAL lymphocytes and a POSITIVE heterophile antibody test.

Question 14

Esptein-Barr Virus. Contains a ___ analogue, which stimulates B-cell growth and proliferation preventing the infected B cell from undergoing apoptosis.

Answer 14

Contains a IL-10 analogue, which stimulates B-cell growth and proliferation preventing the infected B cell from undergoing apoptosis.

Question 15

Esptein-Barr Virus. B cell activation stimulates production of an IgM antibody. This is the ___ antibody.

Answer 15

B cell activation stimulates production of an IgM antibody. This is the HETEROPHILE POSITIVE antibody.

Question 16

Esptein-Barr Virus. ___ Leukoplakia may result in EBV infection in immunocompromised patients. This white plague ___ be scrapped off from the tongue, differentiating it from a Candida infection.

Answer 16

HAIR ORAL leukoplakia may result in EBV infection in immunocompromised patients. This white plague WILL NOT be scrapped off from the tongue, differentiating it from a Candida infection.

Question 17

Esptein-Barr Virus. WIthin the Asian Population, ___ carcinomas are associated with EBV infection.

Answer 17

Within the Asian Population, NASOPHARYNGEAL carcinomas are associated with EBV infection.

Question 18

Esptein-Barr Virus. ___ lymphoma is a monoclonal B-cell lymphoma of the jaw and face found in children in Africa and is associated with a malaria and HIV. These conditions ___ cell immunity and increase the likelihood of an EBV infection to target ___ cells.

Answer 18

BURKITTS lymphoma is a monoclonal B-cell lymphoma of the jaw and face found in children in Africa and is associated with malaria and HIV. These conditions SUPPRESS cell immunity and increase the likelihood of an EBV infection to target B cells.

Question 19

Esptein-Barr Virus. Burkitts lymphoma is typically classified as a ___ infection.

Answer 19

Burkitts lymphoma is typically classified as a CO-infection.

Question 20

Esptein-Barr Virus. Causes infectious ___. The reactive cytotoxic CD8T cells are called ___ cells and are diagnostic.

Answer 20

Causes infectious MONONUCLEOSIS. The reactive cytotoxic CD8T cells are called DOWNEY cells and are a diagnostic.

Question 21

Esptein-Barr Virus. Patients with history of infectious mononucleosis are required to refrain from contact sports for about a year to prevent the spleen from ___.

Answer 21

Patients with a history of infectious mononucleosis are required to refrain from contact sports for about a year to prevent the spleen from RUPTURING.

Question 22

Esptein-Barr Virus. ___ should not be used for treatment since antibodies bind to the drug and manifest in the skin. This results in a ___ hypersensitivity reaction.

Answer 22

PENICILLIN should not be used for treatment since antibodies bind to the drug and manifest in the skin. This results in a TYPE 3 hypersensitivity reaction.

Question 23

Cytomegalovirus. Enveloped, double stranded ___ virus and is a member of the ___ family.

Answer 23

Enveloped, double stranded DNA virus and is a member of the BETAHERPESVIRINAE family.

Question 24

Cytomegalovirus. Replicates within ___ cells and causes both ___ and ___ infections.

Answer 24

Replications within HUMAN cells and causes both LYTIC and LATENT infections.

Question 25

Cytomegalovirus. The virus infects ___ lymphocytes and binds to the host cell membrane, and release it DNA, proteins, and mRNA into the cytoplasm.

Answer 25

The virus infects MONONUCLEAR lymphocytes and binds to the host cell membrane, and releases its DNA, proteins, and mRNA into the cytoplasm.

Question 26

Cytomegalovirus. Most common virus associated with ___ defects.

Answer 26

Most common virus associated with CONGENITAL infections.

Question 27

Cytomegalovirus. Transmission via ___ secretions.

Answer 27

Transmission via BODILY FLUID secretions.

Question 28

Cytomegalovirus. In children, CMV causes the ___ syndrome and in adults, CMV causes a ___ disease.

Answer 28

In children, CMV causes the BLUEBERRY MUFFIN syndrome and in adults, CMV causes a SEXUAL TRANSMITTED disease.

Question 29

Cytomegalovirus. Diagnosis is confirmed with a ___ heterophile antibody test and the presence of a basophilic ____ inclusion.

Answer 29

Diagnosis is confirmed with a NEGATIVE antibody test and the presence of a basophilic OWL EYE inclusion.

Question 30

Cytomegalovirus. Treatment includes ___.

Answer 30

Treatment includes GANCICLOVIR.

Question 31

Cytomegalovirus. Prevents ___ to CD4 and CD8 T cells. Specifically, CMV prevents expression of ___ to CD8 T cells and ___ to antigen presenting cells.

Answer 31

Prevents ANTIGEN PRESENTATION to CD4 and CD8 T cells. Specifically, CMV prevents expression of MHC Class I to CD8 T cells and MHC CLASS II to antigen presenting cells.