Lymphoma

Question 1

What is the 7th most common cause of cancer death

Answer 1

Lymphoma

Question 2

Lymphoma has a predominance for M/F?

Answer 2

Males

Although females are more common for follicular lymphoma

Question 3

At what age can lymphoma occur

Answer 3

all ages

avg age is 42

Question 4

3% of what pts will develop lymphoma

Answer 4

AIDS pts

Question 5

Name two probable contributors of why there is an increase in incidence of AIDS pt developing lymphoma

Answer 5

phenoxyherbicide use and aging of pop.

Question 6

80% of lymphomas are from what origin

Answer 6

B-cell

Question 7

What pathogen is associated with Hodgkin’s

Answer 7

EBV

Question 8

What is the gold standard for lymphoma diagnosis

Answer 8

excisional biopsy

needle biopsy can be used to determine if a mass is lymphomatous BUT to see the histo of it excisional is best

Question 9

What 3 things do clinicians and pathologist have to communicate clearly about

Answer 9

1. certainty of diagnosis
2. quality of material available for interpretation
3. clinical course going to be taken

Question 10

What is the most characteristic feature of B-cell lymphoma

Answer 10

painless LN enlargement

can have a “rubbry” feel

Question 11

What is the predominant classification of lymphoma

Answer 11

nodal presentation

Question 12

what is nodal presentation

Answer 12

invovlemnt of LN and other lymphoid structures like the liver and spleen

Question 13

what is the extra-nodal presentation

Answer 13

rarer and important to recognize bc treatment may be site specific

Question 14

the Ann Arbor staging stages what?

Answer 14

Hodgkins Disease

Question 15

Ann Arbor staging is …

Answer 15

limited and extensive

Question 16

Why is Ann Arbor staging used

Answer 16

to differentiate btwn available treatment options

Question 17

what often has microscopic disease at distant sites demonstrated by subsequent relapse

Answer 17

clinically localized low grade lymphoma

Question 18

what has a greater probability of being pathologically localized

Answer 18

higher grade clinically localized lymphoma

it can also turn widespread but if diagnosed quickly and treated it can be cured

Question 19

what is the main reason staging procedures are chosen

Answer 19

to guide therapy selection

Question 20

what was the main criteria of the NCI working formulation classifcation

Answer 20

morphologic

Question 21

which classification system utilized immunophenotypic and genetic data

Answer 21

REAL and WHO

Question 22

what is the translocation for Follicular lymphoma

Answer 22

t(14,18)

Question 23

what is the translocation for Burkitt’s lymphoma

Answer 23

t(8,14)

Question 24

what is the translocation for mantle cell lymphoma

Answer 24

t(11,14)

Question 25

what is the survival rate for mantle cell lymphoma

Answer 25

3-5 years

Question 26

what are the diagnostic markers for mantle cell

Answer 26

sIgM+ IgD+ CD19,20,79a+ CD5+ 10+/- 11c- 23- 43+.

Question 27

what is the general main marker for indolent lymphoma

Answer 27

KI67

Question 28

Treatment he bolded for mantle cell

Answer 28

Ibrutinib

Question 29

What type of lymphoma is follicular center

Answer 29

generally indolent with widespread disease

Question 30

What are the markers for follicular center

Answer 30

sIgM+/- IgD+ /- CD19,20,79a+ CD5- 10+ 11c- 23-/+ 43-.

Question 31

Marginal zone B-cell lymphoma: extra-nodal ?

Answer 31

Low-grade B-cell Lymphoma of MALT type, ( ± monocytoid B cells)

Question 32

Marginal zone B-cell lymphoma: nodal ?

Answer 32

( ± monocytoid B cells)

Question 33

What disease are Marginal zone B-cell lymphoma associated with?

Answer 33

autoimmune disease related (Sjogren’s, Hashimoto’s), | helicobacter related gastric MALT lymphoma.

Question 34

what are the markers for mantle cell

Answer 34

sIgM+/- IgD+ /- CD19,20,22,79a+ CD5- 10- 11c+/- 23- 43-/+

Question 35

What genetic defect is associated with mantle cell

Answer 35

trisomy 3

Question 36

what kind of lymphoma is mantel cell

Answer 36

indolent and localized cured with local treatment can use Ab to treat h. pylori in gastric MALT lymphoma

Question 37

what is used for advanced NHL

Answer 37

CHOP with 3 intensive chemo

Question 38

what is used in relapses of chemo-sensitive NHL

Answer 38

Autologous Bone marrow transplant (Auto-BMT)

Question 39

What is the only approved treatment for low grade lymphoma

Answer 39

Rituxan -monoclonal Antibody therapy | targets CD20

Question 40

what were rituxan's side effects

Answer 40

fever, chills | occurs mainly on first infusion