Lymphoid Leukemia

Question 1

what is acute leukemia

Answer 1

excess of immature WBC in the blood

Proliferation of BM PRECURSOR cells that accumulate in the marrow or blood

cells fail to differentiate and undergo normal apoptosis

Question 2

what cells are decreased in acute leukemai

Answer 2

normal peripheral blood cells responisble for control of infection, hemostasis and oxygen delviery :
neutrophil, lymphocyte, platelets, RBC

Question 3

So leukemic cells proliferate more rapidly than noraml cells

Answer 3

No

Question 4

Is there anything unique about the cell cycle time of leukemic cells

Answer 4

they are unaltered compared to normal BM cells

Question 5

where do leukemic cells eventually die?

Answer 5

they fail to differentiate and essentially die accumulating in the BM and PB

Question 6

What is ALL

Answer 6

acute lymphoblastic leukemia

- a malignant disease of lymphoid percursor cells

Question 7

What are the risk factors for ALL

Answer 7

Down’s and Bloom’s

Radiation

Question 8

what is the cytogenetics of ALL

Answer 8

increase t(9,22), t(8,14)

Question 9

what is the immunophenotype of ALL

Answer 9

incr expresson of myeloid antigens

decr incidence of pre-B type

Question 10

What is teh drug metabolism of ALL

Answer 10

decr fomration of MTX polyglutamates

incr MDR-1 expression

Question 11

What are some adverse prognosis characteristics of ALL

Answer 11

incr in WBC at diagnosis
slow response to therapy
incr freq mediastinal mass

and these are the reasons why adults have bad prognosis

Question 12

which transplant is helpful in ALL

Answer 12

Allo BMT